105664-71-9

Basic information

• Product Name: (4a,12b-trans)-4-benzoyl-12-methyl-1,2,3,4,4a,5,6,12b-octahydropyrazino<2',3':3,4>pyrido<1,2-a>indole
• Synonyms: (4a,12b-trans)-4-benzoyl-12-methyl-1,2,3,4,4a,5,6,12b-octahydropyrazino<2',3':3,4>pyrido<1,2-a>indole
• CAS NO: 105664-71-9
• Molecular Weight: 345.444
• Mol File: 105664-71-9.mol

Chemical Properties

• CAS DataBase Reference: (4a,12b-trans)-4-benzoyl-12-methyl-1,2,3,4,4a,5,6,12b-octahydropyrazino<2',3':3,4>pyrido<1,2-a>indole(CAS DataBase Reference)
• NIST Chemistry Reference: (4a,12b-trans)-4-benzoyl-12-methyl-1,2,3,4,4a,5,6,12b-octahydropyrazino<2',3':3,4>pyrido<1,2-a>indole(105664-71-9)
• EPA Substance Registry System: (4a,12b-trans)-4-benzoyl-12-methyl-1,2,3,4,4a,5,6,12b-octahydropyrazino<2',3':3,4>pyrido<1,2-a>indole(105664-71-9)

Safety Data

• Hazardous Substances Data: 105664-71-9(Hazardous Substances Data)

Upstream product

• 83-34-1 3-Methylindole 
• 93797-58-1 10-methyl-6,7,8,9-tetrahydropyrido[1,2-a]indol-9-one 
• 93797-57-0 4-(3-Methyl-1H-indol-1-yl)butanoic acid 
• 93797-60-5 8-bromo-6,7,8,9-tetrahydro-10-methylpyrido<1,2-a>indol-9-one 
• 98-88-4 benzoyl chloride 
• 93797-61-6 (4b,12b-trans)-1,2,3,4,4a,5,6,12b-octahydro-12-methylpyrazino<2',3':3,4>pyrido<1,2-a>indole 

Downstream Products

• 105664-68-4 ((4aS,12bR)-1-Ethyl-12-methyl-2,3,4a,5,6,12b-hexahydro-1H-pyrazino[2',3':3,4]pyrido[1,2-a]indol-4-yl)-phenyl-methanone 

Relevant articles and documents

Octahydropyrazinopyridoindoles. A New Class of Potent Antihypertensive Agents

Simplifications and modifications of the vincamine molecule led to the discovery of antihypertensive 1,2,3,4,4a,5,6,12b-octahydro-12-methylpyrazinopyridoindoles.Stereoselective syntheses of both 4a,12b-cis and 4a,12b-trans isomers represent new annulation strategies for the construction of fused piperazines.Compounds of the trans series were at least 10 times more potent than the corresponding cis isomers.Antihypertensive activity and α1-adrenoceptor blocking properties peaked with a simulataneous introduction of 4-methylethyl and 1-alkyl substituents.Compound 15j (AY-28,228: atiprosin), (4a,12b-trans)-1-ethyl- 1,2,3,4,4a,5,6,12b-octahydro-12-methyl-4-(1-methylethyl)pyrazinopyridoindole, was chosen for a detailed preclinical evaluation.