93797-57-0

Basic information

• Product Name: 4-(3-Methyl-1H-indol-1-yl)butanoic acid
• Synonyms: 4-(3-Methyl-1H-indol-1-yl)butanoic acid
• CAS NO: 93797-57-0
• Molecular Weight: 217.268
• Mol File: 93797-57-0.mol

Chemical Properties

• CAS DataBase Reference: 4-(3-Methyl-1H-indol-1-yl)butanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-Methyl-1H-indol-1-yl)butanoic acid(93797-57-0)
• EPA Substance Registry System: 4-(3-Methyl-1H-indol-1-yl)butanoic acid(93797-57-0)

Safety Data

• Hazardous Substances Data: 93797-57-0(Hazardous Substances Data)

Upstream product

• 83-34-1 3-Methylindole 
• 96-48-0 4-butanolide 

Downstream Products

• 93797-97-8 (4aS,12bR)-1-Ethyl-12-methyl-4-(2-phenoxy-ethyl)-1,2,3,4,4a,5,6,12b-octahydro-pyrazino[2',3':3,4]pyrido[1,2-a]indole 
• 93797-78-5 (4aS,12bR)-12-Methyl-4-(2-phenoxy-ethyl)-1,2,3,4,4a,5,6,12b-octahydro-pyrazino[2',3':3,4]pyrido[1,2-a]indole 
• 105664-68-4 ((4aS,12bR)-1-Ethyl-12-methyl-2,3,4a,5,6,12b-hexahydro-1H-pyrazino[2',3':3,4]pyrido[1,2-a]indol-4-yl)-phenyl-methanone 
• 105664-71-9 (4a,12b-trans)-4-benzoyl-12-methyl-1,2,3,4,4a,5,6,12b-octahydropyrazino<2',3':3,4>pyrido<1,2-a>indole 

Relevant articles and documents

Intramolecular Friedel-Crafts Acylation Reaction Promoted by 1,1,1,3,3,3-Hexafluoro-2-propanol

Simple dissolution of an arylalkyl acid chloride in 1,1,1,3,3,3-hexafluoro-2-propanol promotes an intramolecular Friedel-Crafts acylation without additional catalysts or reagents. This reaction is operationally trivial in both execution and product isolation (only requiring concentration followed by purification) and accommodates a broad range of substrates. Preliminary studies that bear upon potential reaction mechanisms are reported.

Method for synthesis of 12H-pyrido[1,2-a:3,4-b']diindoles. Total synthesis of homofascaplysin C

An efficient synthesis of a 12H-pyrido[1,2-a:3,4-b']diindole system is proposed. 3-Methylindole has been converted into homofascaplysin C by a four reaction sequence in which the last step is dehydrogenation and oxidation of the methyl- to formyl group at the same time.

Octahydropyrazinopyridoindoles. A New Class of Potent Antihypertensive Agents

Simplifications and modifications of the vincamine molecule led to the discovery of antihypertensive 1,2,3,4,4a,5,6,12b-octahydro-12-methylpyrazinopyridoindoles.Stereoselective syntheses of both 4a,12b-cis and 4a,12b-trans isomers represent new annulation strategies for the construction of fused piperazines.Compounds of the trans series were at least 10 times more potent than the corresponding cis isomers.Antihypertensive activity and α1-adrenoceptor blocking properties peaked with a simulataneous introduction of 4-methylethyl and 1-alkyl substituents.Compound 15j (AY-28,228: atiprosin), (4a,12b-trans)-1-ethyl- 1,2,3,4,4a,5,6,12b-octahydro-12-methyl-4-(1-methylethyl)pyrazinopyridoindole, was chosen for a detailed preclinical evaluation.

Pyrazino[2',3'-3,4]pyrido[1,2-a]indole derivatives

Herein is disclosed pyrazino[2',3'-3,4]pyrido[1,2-a]indole derivatives, therapeutically acceptable acid addition salts thereof, processes for their preparation, methods of using the derivatives and pharmaceutical compositions. The derivatives are useful for treating hypertension in a mammal.