105707-16-2Relevant academic research and scientific papers
Novel Approach to the Synthesis of 3-amino-4-arylpyridin-2(1H)-one Derivatives
Shuvalov, Vladislav Yu.,Chernenko, Sergei А.,Shatsauskas, Anton L.,Samsonenko, Anna L.,Dmitriev, Maksim V.,Fisyuk, Alexander S.
, p. 764 - 771 (2021/10/04)
[Figure not available: see fulltext.] The reaction of 4-arylidene-2-phenyloxazol-5(4H)-ones with enamines of ethyl acetoacetate gave 4-aryl-2-methyl-6-oxo-5-[(phenylcarbonyl)amino]-1,4,5,6-tetrahydropyridine-3-carboxylic acid esters, which, when heated with phosphorus oxychloride, were converted into esters of 7-aryl-5-methyl-2-phenyloxazolo[5,4-b]pyridine-6-carboxylic acids. Alkaline hydrolysis of these compounds gave 4-aryl-2-methyl-6-oxo-5-[(phenylcarbonyl)amino]-1,6-dihydropyridine-3-carboxylic acid esters.
ETUDE DE LA REACTIVITE D'YLIDENEOXAZOLINE-5-ONES VIS-A-VIS DE COMPOSES ENAMINOCARBONYLES.
Maquestiau, A.,Vanden Eynde, J.-J.,Papleux, P.
, p. 849 - 858 (2007/10/02)
Reactions between 4-ylideneoxazolin-5-ones and enaminocarbonyl compounds do not lead to 4,7-dihydrooxazolopyridines.These reactions yield, by cleavage of the five-membered ring, monocyclic derivatives whose structures are elucidated.Thus, starting from 4-arylideneoxazolin-5-ones, mixtures of cis and trans dihydro-α-pyridones are formed but, in most cases, only the cis isomers can be isolated.Starting from 2-phenyl-4-ethoxymethyleneoxazolin-5-one, reactions proceed, in addition, by loss of ethanol and α-pyridones are obtained.
