1057393-65-3

Basic information

• Product Name: 2,3,5-trifluoro-4-iodopyridine
• Synonyms: 2,3,5-trifluoro-4-iodopyridine
• CAS NO: 1057393-65-3
• Molecular Formula: C₅HF₃IN
• Molecular Weight: 258.9678196
• Mol File: 1057393-65-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 192.7±35.0 °C(Predicted)
• Appearance: /
• Density: 2.206±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: -6.67±0.28(Predicted)
• CAS DataBase Reference: 2,3,5-trifluoro-4-iodopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,5-trifluoro-4-iodopyridine(1057393-65-3)
• EPA Substance Registry System: 2,3,5-trifluoro-4-iodopyridine(1057393-65-3)

Safety Data

• Hazardous Substances Data: 1057393-65-3(Hazardous Substances Data)

Usage

General Description

2,3,5-trifluoro-4-iodopyridine is a chemical compound with the molecular formula C5H2F3IN. It is a halogenated pyridine derivative that is commonly used in pharmaceutical and agrochemical research and development. The compound's unique structure and properties make it valuable in the synthesis of various biologically active molecules and pharmaceutical intermediates. It is also used as a building block in the development of crop protection agents and herbicides. 2,3,5-trifluoro-4-iodopyridine is available in the form of a white to off-white powder and should be handled and stored in accordance with safe laboratory practices and regulations.

Upstream product

• 76469-41-5 2,3,5‐trifluoropyridine 

Relevant articles and documents

Synthesis of Polyflourinated Biphenyls; Pushing the Boundaries of Suzuki-Miyaura Cross Coupling with Electron-Poor Substrates

Polyfluorinated biphenyls are interesting and promising substrates for many different applications. Unfortunately, all current methods for the syntheses of these compounds only work for a hand full of molecules or only in very special cases. Thus, many of these compounds are still inaccessible to date. Here we report a general strategy for the synthesis of a wide range of highly fluorinated biphenyls. In our studies we investigated crucial parameters, such as different phosphine ligands and the influence of various nucleophiles and electrophiles with different degrees of fluorination. These results extend the scope of the already very versatile Suzuki-Miyaura reaction toward the synthesis of very electron-poor products, making these more readily accessible. The presented methodology is scalable and versatile without the need for elaborate phosphine ligands or Pd-precatalysts.

NEW 3-([1,2,4]TRIAZOLO[4,3-A]PYRIDIN-7-YL)BENZAMIDE DERIVATIVES

This invention is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I) to processes for their preparation; to pharmaceutical compositions comprising them; and to their use in therapy.