847802-91-9

Usage

Uses

Used in Pharmaceutical Industry:
6-Hydroxy-N-methyl-1-naphthamide is used as an intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into the molecular structures of various drugs. Its unique functional groups allow for the creation of new medicinal compounds with potential therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical field, 6-Hydroxy-N-methyl-1-naphthamide serves as an intermediate in the production of agrochemicals, such as pesticides and herbicides. Its chemical properties make it suitable for the development of effective compounds targeting agricultural pests and weeds.
Used in Organic Synthesis:
6-Hydroxy-N-methyl-1-naphthamide is utilized as a reagent in organic synthesis, where it can participate in a range of chemical reactions to form diverse organic compounds. Its presence can influence the outcome of these reactions, contributing to the synthesis of complex organic molecules.
Used in Chemical Research:
As a building block for the production of various organic compounds, 6-Hydroxy-N-methyl-1-naphthamide is valuable in chemical research. Scientists use 6-Hydroxy-N-methyl-1-naphthamide to explore new methods of synthesis, investigate its reactivity, and develop novel applications across different industries.

Upstream product

• 2437-17-4 6-hydroxy-1-naphthoic acid 
• 74-89-5 methylamine 
• 593-51-1 methylamine hydrochloride 

Downstream Products

• 1058137-70-4 6-(7-(benzyloxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide 
• 1058137-21-5 benzyl 1-((6-methoxy-4-(5-(methylcarbamoyl)naphthalen-2-yloxy)quinolin-7-yloxy)methyl)cyclo-propylcarbamate 
• 1058137-23-7 lucitanib 

Relevant academic research and scientific papers

PROCESS FOR PREPARING THE ANTI-TUMOR AGENT 6-(7-((1-AMINOCYCLOPROPYL) METHOXY)-6-METHOXYQUINOLIN-4-YLOXY)-N-METHYL-1-NAPHTHAMIDE AND ITS CRYSTALLINE

The present invention relates a new process to synthesize 6-(7-((l-aminocyclo-propyl)- methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl- l -naphthamide (AL3810) by deprotection of substituted benzyl 1 -((6-methoxy-4-(5-(methylcarbamoyl)naphthalen-2-yloxy)quinolin-7-yloxy)- methyl)cyc-lopropylcarbamate (Formula I) under a diluted or weak acidic condition. A stable crystalline form of 6-(7-((l-aminocyclo-propyl)-methoxy)-6-methoxyquinolin-4-yloxy)-N- methyl- 1 -naphthamide has also been prepared.

SPIRO SUBSTITUTED COMPOUNDS AS ANGIOGENESIS INHIBITORS

The present invention relates to spiro (tetracarbon) substituted compound of Formula I, processes for their preparation, pharmaceutical compositions containing them as active ingredient, methods for the treatment of disease states associated with angiogenesis, such as cancers associated with protein tyrosine kinases, to their use as medicaments for use in the production of inhibition of tyrosine kinases reducing effects in warm-blooded animals such as humans

Sulfonamide derivatives for the treatment of diseases

The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in

NAPHTHALENE CARBOXAMIDES AND THEIR DERIVATIVES USEFUL AS NEW ANTI-ANGIOGENIC AGENTS

The invention relates to compounds represented by Formula (I) and to prodrugs thereof, pharmaceutically acceptable salts or solvates of said compounds or said prodrugs, wherein each of R1a-d , R2a-b , R3, and X1 are defined herein, The invention also relates to pharmaceutical compositions containing the compounds of Formula (I) and to methods of treating hyperproliferative disorders in a mammal by administering compounds of Formula(l).