105868-85-7

Basic information

• Product Name: 9-(4-hydroxy-2-(hydroxymethyl)butyl)guanine
• Synonyms: 9-(4-hydroxy-2-(hydroxymethyl)butyl)guanine;2-Amino-1,9-dihydro-9-[4-hydroxy-2-(hydroxymethyl)butyl]-6H-purin-6-one;2-Amino-9-[2-(hydroxymethyl)-4-hydroxybutyl]-6,9-dihydro-1H-purine-6-one;9-[4-Hydroxy-2-(hydroxymethyl)butyl]-2-amino-9H-purin-6(1H)-one
• CAS NO: 105868-85-7
• Molecular Formula: C10H15 N5 O3
• Molecular Weight: 253.26
• Mol File: 105868-85-7.mol

Chemical Properties

• Boiling Point: 637.8°C at 760 mmHg
• Flash Point: 339.5°C
• Appearance: /
• Density: 1.68g/cm³
• Vapor Pressure: 3.85E-17mmHg at 25°C
• Refractive Index: 1.748
• CAS DataBase Reference: 9-(4-hydroxy-2-(hydroxymethyl)butyl)guanine(CAS DataBase Reference)
• NIST Chemistry Reference: 9-(4-hydroxy-2-(hydroxymethyl)butyl)guanine(105868-85-7)
• EPA Substance Registry System: 9-(4-hydroxy-2-(hydroxymethyl)butyl)guanine(105868-85-7)

Safety Data

• Hazardous Substances Data: 105868-85-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H15N5O3/c11-10-13-8-7(9(18)14-10)12-5-15(8)3-6(4-17)1-2-16/h5-6,16-17H,1-4H2,(H3,11,13,14,18)

Upstream product

• 67-56-1 methanol 
• 126617-59-2 dimethyl 2-(2-amino-6-chloropurin-9-ylmethyl)-succinate 
• 121-43-7 Trimethyl borate 
• 112233-74-6 N₂-acetyl-O₆-(diphenylcarbamoyl)guanine 
• 553646-42-7 ethyl 3-(2-N-acetyl-6-O-(diphenylcarbamoyl)guanin-9-ylmethyl)-2-(hydroxymethyl)propanoate 

Relevant articles and documents

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Derivatives of purine, process for their preparation and a pharmaceutical preparation

Antivirally active compounds of formula (I), wherein R1 is hydrogen, hydroxy, mercapto or amino; R2 is hydrogen, hydroxy, fluoro, chloro or amino; R3 and R4 are independently selected from (II), (III), amino, hydroxy or an ether or ester residue thereof, or R3 together with R4 is (IV), wherein M is hydrogen or a pharmaceutically acceptable counterion; and n is 1 or 2; with the proviso that, when R2 is amino and R3 and R4 are hydroxy R1 is not hydroxy and in addition, when n=1, R1 is not hydrogen, and pharmaceutically acceptable salts thereof; processes for preparation of said compounds, a pharmaceutical composition comprising said compounds, methods for treatments of virus infections as well as use of compounds of formula (I) without the proviso for the manufacture of a medicament for treatment of AIDS. STR1

GUANINE DERIVATIVE

Antivirally active compounds of the formula STR1 wherein A is STR2 wherein m is 1 or 2, n is 1 or 2, whereby m is 1 when n is 2 and m is 2 when n is 1, R a ' is (CH 2) p OH, NHCONH 2 or COR a ", R a " is hydrogen, hydroxy or amino, p is 1 to 4, R b ' and R b " are independently selected from hydrogen or (CH 2) p OH, with the proviso that at least one of R b ' or R b " is hydrogen; or R b ' and R b " together constitute an additional carbon-carbon bond to form an alkyne; or a physiologically acceptable salt, geometric or optical isomer thereof; pharmaceutical preparations containing the compounds and methods for treatment of virus infections.