1058712-05-2Relevant academic research and scientific papers
Indium(III) iodide-mediated Strecker reaction in water: an efficient and environmentally friendly approach for the synthesis of α-aminonitrile via a three-component condensation
Shen, Zhi-Liang,Ji, Shun-Jun,Loh, Teck-Peng
, p. 8159 - 8163 (2008)
A mild, efficient and environmentally friendly method has been developed for the synthesis of α-aminonitriles via a three-component condensation of aldehyde, amine and TMSCN in the presence of a catalytic amount of indium(III) iodide in water. The reactions proceeded smoothly at room temperature in water to generate the corresponding products in moderate to excellent yields.
Expeditious and efficient synthesis of Strecker's α-aminonitriles catalyzed by sulfated polyborate
Indalkar, Krishna S.,Khatri, Chetan K.,Chaturbhuj, Ganesh U.
, p. 2144 - 2148 (2017)
A straightforward, mild, efficient, and environmentally benign protocol for a three-component Strecker reaction of aldehydes or ketones, amines, and trimethylsilyl cyanide catalyzed by sulfated polyborate has been described to afford α-aminonitriles under solvent-free reaction conditions. The major advantages of the present method are excellent yields, shorter reaction time, simple experimental procedure, easy workup procedure, recyclability of the catalyst, solvent-free reaction conditions and ability to tolerate a variety of functional groups which gives economical as well as ecological rewards.
Role of (3-aminopropyl)tri alkoxysilanes in grafting of chlorosulphonic acid immobilized magnetic nanoparticles and their application as heterogeneous catalysts for the green synthesis of α-aminonitriles
Singh, Harminder,Rajput, Jaspreet Kaur,Arora, Priya,Jigyasa
, p. 84658 - 84671 (2016/10/31)
The surface modification of SiO2 coated Fe3O4 nanoparticles by grafting silane coupling agents is a highly significant approach to enhancing the interface interaction between the inorganic magnetic core and the organic fun
L-Proline catalyzed one pot synthesis of α-aminonitriles
Nasreen, Aayesha
, p. 3797 - 3800 (2013/07/05)
l-Proline (20 mol %) was found to be an efficient organocatalyst for one pot synthesis of a variety of α-aminonitriles from aldehydes, amines, and trimethylsilyl cyanide (TMSCN) in acetonitrile at ambient temperature giving good to excellent yields (72-95%).
