105902-61-2Relevant articles and documents
Br?nsted Base Assisted Photoredox Catalysis: Proton Coupled Electron Transfer for Remote C?C Bond Formation via Amidyl Radicals
Jia, Jiaqi,Ho, Yee Ann,Bülow, Raoul F.,Rueping, Magnus
, p. 14054 - 14058 (2018)
The synthesis of alkyne- and alkene-decorated lactams has been achieved through a photoredox-initiated radical cascade reaction. The developed Br?nsted base assisted, photoredox-catalyzed, intramolecular 5-exo-trig cyclization/intermolecular radical addit
Formal Aza-Wacker Cyclization by Tandem Electrochemical Oxidation and Copper Catalysis
Yi, Xiangli,Hu, Xile
supporting information, p. 4700 - 4704 (2019/03/07)
In oxidative electrochemical organic synthesis, radical intermediates are often oxidized to cations on the way to final product formation. Herein, we describe an approach to transform electrochemically generated organic radical intermediates into neutral
An Easy-to-Machine Electrochemical Flow Microreactor: Efficient Synthesis of Isoindolinone and Flow Functionalization
Folgueiras-Amador, Ana A.,Philipps, Kai,Guilbaud, Sébastien,Poelakker, Jarno,Wirth, Thomas
supporting information, p. 15446 - 15450 (2017/11/10)
Flow electrochemistry is an efficient methodology to generate radical intermediates. An electrochemical flow microreactor has been designed and manufactured to improve the efficiency of electrochemical flow reactions. With this device only little or no supporting electrolytes are needed, making processes less costly and enabling easier purification. This is demonstrated by the facile synthesis of amidyl radicals used in intramolecular hydroaminations to produce isoindolinones. The combination with inline mass spectrometry facilitates a much easier combination of chemical steps in a single flow process.