105905-60-0

Basic information

• Product Name: 3,4-DIETHOXY-BENZOYL CHLORIDE
• Synonyms: 3,4-DIETHOXY-BENZOYL CHLORIDE;benzoyl chloride, 3,4-diethoxy-
• CAS NO: 105905-60-0
• Molecular Formula: C₁₁H₁₃ClO₃
• Molecular Weight: 228.67
• Mol File: 105905-60-0.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3,4-DIETHOXY-BENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DIETHOXY-BENZOYL CHLORIDE(105905-60-0)
• EPA Substance Registry System: 3,4-DIETHOXY-BENZOYL CHLORIDE(105905-60-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 105905-60-0(Hazardous Substances Data)

Upstream product

• 5409-31-4 3,4-diethoxybenzoic acid 

Downstream Products

• 855269-82-8 3,4-diethoxy-benzoic acid-(4-ethoxy-3-methoxy-phenethylamide) 
• 42420-04-2 3,4-Diethoxy-N-isobutyl-benzamide 
• 568544-09-2 N-[(3,4-diethoxyphenyl)carbonyl]glycine 
• 1477751-75-9 N-(4-((3-chlorophenyl)amino)quinazolin-6-yl)-3,4-diethoxybenzamide 
• 1608146-63-9 N-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2-iodophenyl)acetamide 
• 333322-82-0 2-(3,4-diethoxyphenyl)-5-(pyridin-4-yl)-1,3,4-oxadiazole 
• 102762-85-6 6,7-diethoxy-1-(3,4-diethoxy-phenyl)-3,4-dihydro-isoquinoline 
• 122892-62-0 N-[4-(2-Dimethylamino-ethoxy)-benzyl]-3,4-diethoxy-benzamide 
• 99499-11-3 3,4-Diethoxy-N-propyl-benzamide 
• 42420-19-9 4-(3,4-diethoxy-benzoyl)-morpholine 
• 101108-33-2 3,4-diethoxy-benzoic acid diethylamide 
• 349446-71-5 3,4-diethoxy-benzoic acid amide 

Relevant articles and documents

Synthesis and structure-activity relationship of non-peptidic antagonists of neuropilin-1 receptor

Neuropilins (NRPs) are VEGF-A165 co-receptors over-expressed in tumor cells, and considered as targets in angiogenic-related pathologies. We previously identified compound 1, the first non-peptidic antagonist of the VEGF-A165/NRP binding, which exhibits in vivo anti-angiogenic and anti-tumor activities. We report here the synthesis and biological evaluations of new antagonists structurally-related to compound 1. Among these molecules, 4a, 4c and 4d show cytotoxic effects on HUVEC and MDA-MB-31 cells, and antagonize VEGF-A165/NRP-1 binding. This study confirmed our key structure-activity relationships hypothesis and paved the way to compound 1 'hit to lead' optimization.

Small-Molecule Choline Kinase Inhibitors as Anti-Cancer Therapeutics

Small molecule choline kinase inhibitors having the following formula: are provided herein. Also provided herein are pharmaceutical compositions containing Formula I compounds, together with methods of treating cancer, methods of inhibiting choline kinase enzymatic activity, and methods of treating tumors by administering an effective amount of a Formula I compound.

Novel acyl coenzyme A: Diacylglycerol acyltransferase 1 inhibitors - Synthesis and biological activities of N-(substituted heteroaryl)-4-(substituted phenyl)-4-oxobutanamides

In a program to discover new small molecule diacylglycerol acyltransferase (DGAT)-1 inhibitors, screening of our in-house chemical library was carried out using recombinant human DGAT-1 enzyme. From this library, the lead compound 1a was identified as a n