105907-63-9

Upstream product

• 53269-35-5 3-formyl-1H-indole-4-carbonitrile 
• 124-40-3 dimethyl amine 
• 113551-14-7 (4-cyano-indol-3-ylmethyl)-trimethyl-ammonium; iodide 
• 24621-73-6 4-chloro-1H-indole-2-carboxylic acid 
• 16136-52-0 4-cyanoindole 
• 50-00-0 formaldehyd 
• 506-59-2 N,N-dimethylammonium chloride 
• 83-42-1 6-chloro-2-nitrotoluene 
• 67-56-1 methanol 
• 36892-19-0 (2-chloro-6-nitro-phenyl)-pyruvic acid 

Downstream Products

• 100136-36-5 3-(4-cyano-indol-3-yl)-propionic acid 

Relevant academic research and scientific papers

TRIAZOLE BETA CARBOLINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS

Beta-carboline derivatives of structural formula (I) are selective antagonists of the somatostatin subtype receptor 3 (SSTR3) and are useful for the treatment of Type 2 diabetes mellitus and of conditions that are often associated with this disease, including hyperglycemia, insulin resistance, obesity, lipid disorders, and hypertension. The compounds are also useful for the treatment of depression and anxiety.

A SYNTHESIS METHOD OF INDOLE-3-METHANAMINE AND/OR GRAMINE FROM INDOLE-3-CARBOXALDEHYDE, AND ITS APPLICATION FOR THE SYNTHESES OF BRASSININ, ITS 4-SUBSTITUTED ANALOGS, AND 1,3,4,5-TETRAHYDROPYRROLOQUINOLINE

Simple conversion method of indole-3-carboxaldehyde into gramine and/or indole-3-methanamine was developed.The present method realized short step syntheses of brassinin, 4-iodo-, methoxy-, 4-methoxy, and 4-nitrobrassinin, 4-methoxyindole-3-acetonitrile, and 1,3,4,5-tetrahydropyrroloquinoline.