105909-48-6Relevant academic research and scientific papers
Palladium-catalyzed electrophilic C–H fluorination of arenes using oxazoline as a removable directing group
Gutierrez, David A.,Lee, Wan-Chen Cindy,Shen, Yuning,Li, Jie Jack
supporting information, p. 5372 - 5376 (2016/11/11)
Dimethyloxazoline was rationally designed to act as a removable ortho-directing group (DG) for the palladium-catalyzed C–H electrophilic fluorination of arenes. Using NFSI as the fluorinating agent, and Pd(II), Ag(I) catalytic system, electrophilic C(sp2–H) ortho-fluorination took place on a variety of aryl substrates to afford the corresponding mono- and di-fluorinated products.
