98191-99-2

Usage

Chemical structure

2-(2-chlorophenyl)-4,5-dihydro-4,4-dimethyloxazole

Class

Antiarrhythmic drugs

Mechanism of action

Blocks sodium channels in the heart

Purpose

Stabilizes heart rhythm and prevents abnormal heartbeats

Primary use

Treating certain types of irregular heartbeats (arrhythmias)

Additional benefit

Helps prevent sudden cardiac death in people who have had a heart attack

Form

Oral

Prescription type

Long-term treatment for chronic arrhythmias

Potential applications

Treatment of chronic pain and neuropathic disorders

Upstream product

• 124-68-5 2-Amino-2-methyl-1-propanol 
• 30457-12-6 (1H-benzo[d][1,2,3]triazol-1-yl)(2-chlorophenyl)methanone 
• 69-72-7 salicylic acid 
• 89-98-5 2-chloro-benzaldehyde 
• 118-91-2 ortho-chlorobenzoic acid 
• 609-65-4 o-chlorobenzoyl chloride 
• 105909-48-6 2-(2-chloro-benzoylamino)-2-methyl-propan-1-ol 

Downstream Products

• 57629-47-7 2-(2-Butylphenyl)-4,4-dimethyl-2-oxazoline 
• 84392-32-5 4,4-dimethyl-2-(4'-methyl-biphenyl-2-yl)-4,5-dihydrooxazole 
• 16064-04-3 2-(4-methoxyphenyl)benzaldehyde 
• 142598-69-4 2-(naphthalene-1-yl)benzaldehyde 
• 156641-63-3 4,4-dimethyl-2-<2-(2-methylphenyl)phenyl>-1,3-oxazoline 

Relevant academic research and scientific papers

Preparation method of 5-bromo-2-chlorobenzoic acid

The invention relates to a preparation method of 5-bromo-2-chlorobenzoic acid. The preparation method comprises the following steps: taking 2-chlorobenzoic acid as an initial reactant, sequentially carrying out chlorination, acylation and cyclization reactions to obtain a protective group o-chlorobenzoic acid (a compound represented by formula III), and sequentially carrying out bromination and hydrolysis to obtain 5-bromo-2-chlorobenzoic acid. The reaction conditions are mild, and the safety of the preparation process is improved. The yield of the prepared product can reach 75% or above, thepurity can reach 99% or above, and the purity and yield are much higher than those of an existing preparation method. Meanwhile, the preparation method is simple in process step, the product is easy to purify, 5-bromo-2-chlorobenzoic acid can be synthesized on a large scale, and the preparation method has a good industrial development prospect.

Palladium-catalyzed electrophilic C–H fluorination of arenes using oxazoline as a removable directing group

Dimethyloxazoline was rationally designed to act as a removable ortho-directing group (DG) for the palladium-catalyzed C–H electrophilic fluorination of arenes. Using NFSI as the fluorinating agent, and Pd(II), Ag(I) catalytic system, electrophilic C(sp2–H) ortho-fluorination took place on a variety of aryl substrates to afford the corresponding mono- and di-fluorinated products.

Directed functionalization of halophenyl-2-oxazolines with TMPMgCl?LiCl

A variety of difunctionalized aryl-2-oxazolines were prepared from the reaction of halophenyl-2-oxazolines and TMPMgCl?LiCl to give an organomagnesium reagent, which was then treated with various electrophiles. The metalation step takes place under mild conditions, and this process al-lows for the isolation of the desired products in good yields. No isomeric or other benzyne-derived products were detected. The influence of the halogen substituents on the acidity of the aromatic hydrogen atoms was evaluated by using density functional theory (DFT) calculations.

A novel and direct synthesis of 1,3,4-oxadiazoles or oxazolines from carboxylic acids using cyanuric chloride/indium

Direct synthesis of various oxazolines and 1,3,4-oxadiazoles from carboxylic acids was achieved using cyanuric chloride/indium under very mild conditions.

Facile Syntheses of Oxazolines and Thiazolines with N-Acylbenzotriazoles under Microwave Irradiation

Microwave reactions of 2-amino-2-methyl-1-propanol (2) or 2-aminoethanethiol hydrochloride (4) with readily available N-acylbenzotriazoles 1a-j in the presence of SOCl2 produced 2-substituted 2-oxazolines 3a-j in 84-98% yields and 2-substituted