10591-92-1

Upstream product

• 110-89-4 piperidine 
• 17082-13-2 α-bromoacetophenone oxime 
• 100-42-5 styrene 
• 100-75-4 N-nitrosopiperidine 
• 40814-66-2 (Z)-2-chloro-1-phenylethan-1-one oxime 
• 4641-62-7 1-phenyl-2-piperidino-ethanone; hydrochloride 

Downstream Products

• 42564-23-8 2-Phenyl-6,7,8,8a-tetrahydro-3H,5H-imidazo<1,2-a>pyridin-1-oxid 
• 139881-90-6 (E)-α-(2-phenylpiperidin-1-yl)acetophenone oxime 
• 139881-92-8 (E)-1-Phenyl-O-(phenylcarbamoyl)-2-(2-phenylpiperidino)-ethanonoxim 
• 139881-91-7 (E)-2-(2-Methylpiperidino)-1-phenyl-O-(phenylcarbamoyl)-ethanonoxim 
• 139881-97-3 8a-Methyl-2-phenyl-3,5,6,7,8,8a-hexahydro-imidazo<1,2-a>pyridin-1-oxid 
• 16451-61-9 (E)-1-Phenyl-2-(2-methylpiperidino)-ethanonoxim 
• 41208-22-4 1-(2-Amino-2-phenyl-ethyl)piperidin 

Relevant academic research and scientific papers

Visible-Light-Induced Photoaddition of N-Nitrosoalkylamines to Alkenes: One-Pot Tandem Approach to 1,2-Diamination of Alkenes from Secondary Amines

The generation of aminium radical cation species from N-nitrosoamines is disclosed for the first time through visible-light excitation at 453 nm. The developed visible-light-promoted photoaddition reaction of N-nitrosoamines to alkenes was combined with the o-NQ-catalyzed aerobic oxidation protocol of amines to telescope the direct handling of harmful N-nitroso compounds, where the desired α-amino oxime derivatives were obtained in a one-pot tandem N-nitrosation and photoaddition sequence.

Ring cleavage of 2-phenyl-3,5,6,7,8,8a-hexahydro-imidazo[1,2-a]pyridin-1-oxide by substitution

The cyclic α-amino nitrone 2 reacts with Grignard reagents yielding the ring opened 2-substituted piperidine oximes 7 and 8, but not the substituted cyclic hydroxylamines of type 4, a formerly supposed. The structures of 7 and 8 were proved by unequivocal

STEREOCHEMISTRY OF α-AMINOACETOPHENONE OXIMES STUDY OF SOLVENT EFFECTS

The aminolysis of Z-α-halogenoacetophenone oximes results in different mixtures of E- and Z-α-aminoacetophenone oximes depending on the solvent used.Assignment of configuration can be achieved by 13C NMR spectroscopy even if only one isomer is available using a strong solvent dependence of the methylene chemical shift in the case of the Z-isomers.This effect is due to the presence of different conformations in the solvents chloroform and dimethyl sulfoxide.Together with a study by vapor pressure osmometry the results provide an unambiguous proof of intramolecular hydrogen bonding of Z-α-aminoacetophenone oximes in chloroform.