1059189-63-7

Basic information

• Product Name: (2R,3R)-N-tert-butoxycarbonyl-3-amino-4-(4-benzyloxyphenyl)-1-chloro-2-hydroxybutane
• CAS NO: 1059189-63-7
• Molecular Weight: 405.922
• Mol File: 1059189-63-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2R,3R)-N-tert-butoxycarbonyl-3-amino-4-(4-benzyloxyphenyl)-1-chloro-2-hydroxybutane(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3R)-N-tert-butoxycarbonyl-3-amino-4-(4-benzyloxyphenyl)-1-chloro-2-hydroxybutane(1059189-63-7)
• EPA Substance Registry System: (2R,3R)-N-tert-butoxycarbonyl-3-amino-4-(4-benzyloxyphenyl)-1-chloro-2-hydroxybutane(1059189-63-7)

Safety Data

• Hazardous Substances Data: 1059189-63-7(Hazardous Substances Data)

Usage

General Description

The chemical compound "(2R,3R)-N-tert-butoxycarbonyl-3-amino-4-(4-benzyloxyphenyl)-1-chloro-2-hydroxybutane" is a chiral compound with a molecular formula C23H29ClNO4. It is a derivative of amino alcohol and contains a chlorine atom and a benzyl group. The compound is commonly used in organic synthesis and pharmaceutical research, particularly in the development of potential drug candidates. The tert-butoxycarbonyl (Boc) protecting group is often used in organic chemistry to selectively protect the amino group, while the benzyloxyphenyl group provides stability and can be used for further chemical modifications. Due to its structural complexity and functional groups, the compound has potential applications in medicinal chemistry and drug development.

Upstream product

• 152438-62-5 (S)-N-[3-Chloro-2-oxo-1-[[4-(phenylmethoxy)phenyl]methyl]propyl]carbamic acid 1,1-dimethylethyl ester 
• 2130-96-3 O-benzyl-N-tert-butoxycarbonyl-L-tyrosine 
• 1026977-99-0 C₂₆H₃₃NO₇ 
• 114645-18-0 [1-(4-benzyloxy-benzyl)-3-diazo-2-oxo-propyl]-carbamic acid tert-butyl ester 
• 127132-32-5 ethyl N-{[(1,1-dimethylethyl)oxy]carbonyl}-O-(phenylmethyl)-L-tyrosinate 

Relevant articles and documents

PROCESS FOR PRODUCING AMINOEPOXIDE

The present invention relates to a method of producing N-carbamate protected-3-amino-1,2-epoxy-4-(hydroxy substituted phenyl)butane at a high optical purity in a high yield, by hydrogenating N-carbamate protected-3-amino-1-chloro-2-hydroxy-4-(benzyloxy su

Aminodiol HIV protease inhibitors. Synthesis and structure - Activity relationships of P1/P1′ compounds: Correlation between lipophilicity and cytotoxicity

A series of novel aminodiol inhibitors of HIV protease based on the lead compound 1 with structural modifications at P1′ were synthesized in order to reduce the cytotoxicity of 1. We have observed a high degree of correlation between the lipophilicity and the cytotoxicity of this series of inhibitors. It was found that appropriate substitution at the para position of the P1′ phenyl group of 1 resulted in the identification of equipotent (both against the enzyme and in cell culture) compounds (101, 10m, 10n, and 15c) which possess significantly decreased cytotoxicity.