114645-18-0

Usage

Uses

Used in Organic Synthesis:
(S)-3-BOC-AMINO-1-DIAZO-3-(4'-BENZYLOXY)PHENYL-2-BUTANONE is used as a reagent for the introduction of the diazo group into other molecules. This application is crucial in organic synthesis, as the diazo group can be employed in various reactions to modify or functionalize target molecules, leading to the formation of new compounds with different properties and applications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (S)-3-BOC-AMINO-1-DIAZO-3-(4'-BENZYLOXY)PHENYL-2-BUTANONE may have potential applications in the development of new pharmaceuticals. Its unique structure and reactivity can be harnessed to create novel drug candidates with specific biological activities, potentially leading to the discovery of new treatments for various diseases and conditions.
Safety Precautions:
Due to the potential hazards associated with the diazo group in (S)-3-BOC-AMINO-1-DIAZO-3-(4'-BENZYLOXY)PHENYL-2-BUTANONE, it is essential to handle (S)-3-BOC-AMINO-1-DIAZO-3-(4'-BENZYLOXY)PHENYL-2-BUTANONE with extreme caution. Proper safety measures, including the use of personal protective equipment and adherence to established laboratory protocols, should be implemented when working with (S)-3-BOC-AMINO-1-DIAZO-3-(4'-BENZYLOXY)PHENYL-2-BUTANONE. Additionally, it should only be used in a controlled laboratory setting to minimize the risk of accidental exposure or decomposition.

Upstream product

• 70-25-7 N-Methyl-N'-nitro-N-nitrosoguanidine 
• 2130-96-3 O-benzyl-N-tert-butoxycarbonyl-L-tyrosine 
• 543-27-1 isobutyl chloroformate 
• 186581-53-3 diazomethane 
• 1026977-99-0 C₂₆H₃₃NO₇ 

Downstream Products

• 127106-65-4 4-(4-benzyloxy-phenyl)-3-tert-butoxycarbonylamino-butyric acid methyl ester 
• 162541-08-4 ((S)-3-((S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-2-hydroxy-1-{4-[2-(3-methyl-2-oxo-imidazolidin-1-yl)-ethoxy]-benzyl}-propyl)-carbamic acid tert-butyl ester 
• 162540-90-1 ((S)-3-((S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-2-hydroxy-1-{4-[2-(2-oxo-oxazolidin-3-yl)-ethoxy]-benzyl}-propyl)-carbamic acid tert-butyl ester 
• 162541-14-2 {(S)-3-((S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-1-[4-(2-dimethylcarbamoyloxy-ethoxy)-benzyl]-2-hydroxy-propyl}-carbamic acid tert-butyl ester 
• 175233-61-1 Morpholine-4-carboxylic acid 4-[(S)-2-tert-butoxycarbonylamino-4-((S)-3-tert-butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-3-hydroxy-butyl]-benzyl ester 
• 162540-49-0 {(S)-3-((S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-2-hydroxy-1-[4-(2-imidazol-1-yl-ethoxy)-benzyl]-propyl}-carbamic acid tert-butyl ester 
• 162540-84-3 {(S)-3-((S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-2-hydroxy-1-[4-(2-oxo-2-piperidin-1-yl-ethoxy)-benzyl]-propyl}-carbamic acid tert-butyl ester 
• 162541-04-0 {(S)-3-((S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-2-hydroxy-1-[4-(2-hydroxy-2-methyl-propoxy)-benzyl]-propyl}-carbamic acid tert-butyl ester 
• 162539-58-4 [(S)-1-(4-Benzyloxy-benzyl)-3-((S)-3-tert-butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-2-hydroxy-propyl]-carbamic acid tert-butyl ester 
• 162540-93-4 {4-[(S)-2-tert-Butoxycarbonylamino-4-((S)-3-tert-butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-3-hydroxy-butyl]-phenoxy}-acetic acid 
• 175417-50-2 {(S)-3-((S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-2-hydroxy-1-[4-(2-hydroxy-propoxy)-benzyl]-propyl}-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

α- and β-Substituted phosphonate analogs of LPA as autotaxin inhibitors

Autotaxin (ATX) is an attractive pharmacological target due to its lysophospholipase D activity which leads to the production of lysophosphatidic acid (LPA). Blockage of ATX produced LPA by small molecules could be a potential anticancer chemotherapy. In our previous study, we have identified the two β-hydroxy phosphonate analogs of LPA (compounds f17 and f18) as ATX inhibitors. With this work, we investigated α- and β-substituted phosphonate analogs of LPA and evaluated them for ATX inhibitory activity. The stereochemistry of β-hydroxy phosphonates was also studied.

Direct synthesis of N-protected β-amino dimethylhydroxamates: Application to the solid-phase synthesis of a peptide incorporating a new amide bond surrogate ψ[CH2CH2NH]

A rapid and efficient one-step synthesis of N-protected β-amino dimethylhydroxamates starting from diazo ketones is reported. A Fmoc- protected β-amino aldehyde obtained by reduction of its corresponding dimethylhydroxamate was incorporated during solid p

Aminodiol HIV protease inhibitors. Synthesis and structure - Activity relationships of P1/P1′ compounds: Correlation between lipophilicity and cytotoxicity

A series of novel aminodiol inhibitors of HIV protease based on the lead compound 1 with structural modifications at P1′ were synthesized in order to reduce the cytotoxicity of 1. We have observed a high degree of correlation between the lipophilicity and the cytotoxicity of this series of inhibitors. It was found that appropriate substitution at the para position of the P1′ phenyl group of 1 resulted in the identification of equipotent (both against the enzyme and in cell culture) compounds (101, 10m, 10n, and 15c) which possess significantly decreased cytotoxicity.

Retrocarbamate protease inhibitors

The invention discloses compounds of the formula STR1 are disclosed as HIV protease inhibitors.