1059618-10-8

Upstream product

• 770719-12-5 [4-bromo-3-(3-chloro-5-cyanophenoxy)-2-fluorophenyl]acetic acid ethyl ester 
• 6575-00-4 3,5-dichlorobenzonitrile 
• 473923-96-5 3-chloro-5-methoxybenzonitrile 
• 473923-97-6 3-chloro-5-hydroxybenzonitrile 
• 770719-09-0 3-chloro-5-[(2,3-difluoro-6-nitrophenyl)oxy]benzonitrile 
• 867367-05-3 1,1-dimethylethyl ethyl {3-[(3-chloro-5-cyanophenyl)oxy]-2-fluoro-4-nitrophenyl} propanedioate 
• 770719-10-3 [3-(3-chloro-5-cyanophenoxy)-2-fluoro-4-nitrophenyl]acetic acid ethyl ester 
• 770719-11-4 ethyl {4-amino-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetate 

Downstream Products

• 1094342-00-3 3-[(6-bromo-3-{[5-(3-chloro-4-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]-5-chlorobenzonitrile 
• 1094342-02-5 2-[(3-chloro-5-cyanophenyl)oxy]-4-{[5-(3-chloro-4-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-3-fluorobenzonitrile 
• 1094342-03-6 3-chloro-5-[(3-{[5-(3-chloro-4-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-6-ethenyl-2-fluorophenyl)oxy]benzonitrile 
• 1094342-04-7 3-[(6-bromo-3-{[5-(3-chloro-1-oxido-4-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]-5-chlorobenzonitrile 
• 1093988-62-5 3-({6-bromo-2-fluoro-3-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]phenyl}oxy)-5-chlorobenzonitrile 
• 1093988-63-6 2-[(3-chloro-5-cyanophenyl)oxy]-3-fluoro-4-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]benzonitrile 

Relevant academic research and scientific papers

CHEMICAL COMPOUNDS

The present invention relates to compounds that are a non-nucleoside reverse transcriptase inhibitors, and to processes for the preparation and use of the same. Specifically, the present invention includes methods of using such compounds in the treatment of human immunodeficiency virus infection.

CHEMICAL COMPOUNDS

The present invention relates to compounds that are a non-nucleoside reverse transcriptase inhibitors, and to processes for the preparation and use of the same. Specifically, the present invention includes methods of using such compounds in the treatment of human immunodeficiency virus infection.

Discovery of triazolinone non-nucleoside inhibitors of HIV reverse transcriptase

Novel non-nucleoside inhibitors of HIV-RT that contain pyridazinone isosteres were prepared, and a series of triazolinones were found to be potent inhibitors of HIV replication. These compounds were active against several NNRTI-resistant virus strains. Ph