105995-50-4

Upstream product

• 2414-98-4 magnesium ethylate 
• 77359-11-6 propanedioic acid mono[(4-nitrophenyl)methyl] ester 

Downstream Products

• 124-38-9 carbon dioxide 
• 126027-12-1 4-tert-Butoxycarbonylamino-3-oxo-butyric acid 4-nitro-benzyl ester 
• 126027-13-2 (S)-4-Acetylamino-3-oxo-pentanoic acid 4-nitro-benzyl ester 
• 126027-03-0 (S)-4-tert-Butoxycarbonylamino-6-methylsulfanyl-3-oxo-hexanoic acid 4-nitro-benzyl ester 
• 126027-17-6 (S)-4-Benzyloxycarbonylamino-5-(4-hydroxy-phenyl)-3-oxo-pentanoic acid 4-nitro-benzyl ester 
• 126027-14-3 (S)-4-(9H-Fluoren-9-ylmethoxycarbonylamino)-5-methyl-3-oxo-hexanoic acid 4-nitro-benzyl ester 
• 126027-15-4 (S)-4-tert-Butoxycarbonylamino-3-oxo-5-phenyl-pentanoic acid 4-nitro-benzyl ester 
• 126027-04-1 (S)-4-Benzyloxycarbonylamino-3-oxo-5-phenyl-pentanoic acid 4-nitro-benzyl ester 
• 126045-65-6 (4S,5R)-5-Benzyloxy-4-tert-butoxycarbonylamino-3-oxo-hexanoic acid 4-nitro-benzyl ester 
• 126027-18-7 (S)-5-(4-Benzyloxy-phenyl)-4-tert-butoxycarbonylamino-3-oxo-pentanoic acid 4-nitro-benzyl ester 
• 126027-20-1 C₂₇H₃₅N₅O₉S 
• 126027-05-2 (S)-4-tert-Butoxycarbonylamino-5-(1H-indol-3-yl)-3-oxo-pentanoic acid 4-nitro-benzyl ester 
• 126027-06-3 (S)-8-tert-Butoxycarbonylamino-4-(9H-fluoren-9-ylmethoxycarbonylamino)-3-oxo-octanoic acid 4-nitro-benzyl ester 
• 76347-45-0 p-nitrobenzyl (3RS,4RS)-4-<3-<(1RS)-1-p-nitrobenzyloxycarbonyloxyethyl>-2-oxoazetidin-4-yl>-3-oxobutanoate 

Relevant academic research and scientific papers

PROCESS FOR THE PREPARATION OF CARBAPENEM COMPOUNDS

The present invention relates to a process for the preparation of carbapenem compound of Formula (I), wherein P1 is hydrogen or a carboxyl protecting group, P3 is hydrogen or a hydroxyl protecting group, R1 is C1-3 alkyl, and A is selected from a group consisting of a) Formula (II), b) Formula (III), c) Formula (IV), d) Formula (V), e) Formula (VI), f) Formula (VII), wherein P2 is hydrogen or an amino protecting group, R2 and R3 may be same or different and are hydrogen, C1-5 alkyl, optionally substituted aryl, or optionally substituted heteroaryl, and X1 is O or S, or its stereoisomers, or salts thereof.

PROCESS FOR THE PREPARATION OF CARBAPENEM COMPOUNDS

The present invention relates to a process for the preparation of carbapenem compound of Formula (I), wherein P1 is hydrogen or a carboxyl protecting group, P3 is hydrogen or a hydroxyl protecting group, R1 is C1-3 alkyl, and A is selected from a group consisting of a) Formula (II), b) Formula (III), c) Formula (IV), d) Formula (V), e) Formula (VI), f) Formula (VII), wherein P2 is hydrogen or an amino protecting group, R2 and R3 may be same or different and are hydrogen, C1-5 alkyl, optionally substituted aryl, or optionally substituted heteroaryl, and X1 is O or S, or its stereoisomers, or salts thereof.

4-substituted 3-oxobutanoate ester derivatives

This invention relates to a process for preparing 4-substituted 3-oxobutanoate ester derivatives by reaction of essentially anhydrous magnesium malonate monoester salts with activated acyl compounds.

TOTAL SYNTHESIS OF THE CARBAPENEM ANTIBIOTIC (+/-)-6-epi PS-5

A ten-step total synthesis of the carbapenem antibiotic (+/-)-6-epi PS-5 is described starting from trans-2-hexenal and proceeding through the key intermediate cis-(+/-)-3-ethyl-4-oxo-2-azetidineacetic acid. 6-epi PS-5 was tested in vitro and compared with the natural trans isomer.M.I.C. values are reported.