106004-11-9

Upstream product

• 62638-06-6 dimethyl cyclohexane-1,3-dicarboxylate 
• 107-04-0 1-Bromo-2-chloroethane 
• 3971-31-1 cyclohexane-1,3-dicarboxylic acid 
• 106004-10-8 dimethyl 1-(2'-chloroethyl)cyclohexane-1,3-dicarboxylate 
• 1459-93-4 dimethyl Isophthalate 

Downstream Products

• 110371-27-2 bicyclo[3.2.1]octane-1,5-dicarboxylic acid monomethyl ester 
• 1383973-53-2 benzyl 5-aminobicyclo[3.2.1]octan-1-ylcarbamate 
• 1383973-50-9 N-(5-aminobicyclo[3.2.1]octan-1-yl)-3-fluorobenzamide 
• 1383973-78-1 methyl 5-aminobicyclo[3.2.1]octane-1-carboxylate 
• 1396379-54-6 benzyl 5-carbamoylbicyclo[3.2.1]octan-1-ylcarbamate 
• 1383973-81-6 benzyl 5-(2-methylpyrimidin-4-ylcarbamoyl)bicyclo[3.2.1]octan-1-ylcarbamate 
• 1383971-61-6 N,N'-(bicyclo[3.2.1]octane-1,5-diyl)bis(6-methylpicolinamide) 
• 1383971-60-5 N-(5-(3-chlorobenzamido)bicyclo[3.2.1]octan-1-yl)-6-methylpicolinamide 

Relevant academic research and scientific papers

BICYCLO[3.2.1]OCTYL AMIDE DERIVATIVES AND USES OF SAME

The present invention provides bicyclo[3.2.1]octyl amide derivatives of formula (I): wherein L, R1 and R2 are as defined herein, or a pharmaceutically acceptable salt thereof; pharmaceutical compositions and methods using the same.

Synthesis of Bridgehead-Bridgehead Substituted Bicycloalkanes

A convenient synthetic route to several bicycloalkanes bearing substitution at both bridgehead positions is described.The two-step procedure, which involves alkylation of the monoenolates of readily available cyclohexane diesters with 1,2-dihaloethane followed by a base-inducted cyclization of the derived haloethylated product, was successfully applied to the synthesis of dimethyl bicyclooctane-1,4-dicarboxylate, dimethyl bicycloheptane-1,4-dicarboxylate and dimethyl bicyclooctane-1,5-dicarboxylate.Additionally, it was found that the two latter diesters could be obtained in quite acceptable yields in a one-pot procedure through their corresponding cyclohexyl bisenolate precursors.