106004-10-8

Usage

Common Uses

Crosslinking agent in polymer and resin production
Production of plasticizers
Solvent

Hazardous Nature

Yes

Toxicity

Skin irritation
Eye irritation
Respiratory irritation

Carcinogenic Potential

Potential carcinogen

Mutagenic Potential

Potential mutagen

Safety Measures

Handle with caution and follow proper safety protocols when working with this chemical

Upstream product

• 62638-06-6 dimethyl cyclohexane-1,3-dicarboxylate 
• 107-04-0 1-Bromo-2-chloroethane 
• 3971-31-1 cyclohexane-1,3-dicarboxylic acid 
• 1459-93-4 dimethyl Isophthalate 

Downstream Products

• 110371-27-2 bicyclo[3.2.1]octane-1,5-dicarboxylic acid monomethyl ester 
• 106004-11-9 dimethyl bicyclo<3.2.1>octane-1,5-dicarboxylate 
• 1383973-51-0 methyl 5-(benzyloxycarbonylamino)bicyclo[3.2.1]octane-1-carboxylate 
• 1383973-52-1 5-(benzyloxycarbonylamino)bicyclo[3.2.1]octane-1-carboxylic acid 
• 1383973-53-2 benzyl 5-aminobicyclo[3.2.1]octan-1-ylcarbamate 
• 1383973-54-3 benzyl (5-(3-fluorobcnzamido)bicyclo[3.2.1]octan-1-yl)carbamate 
• 1383973-50-9 N-(5-aminobicyclo[3.2.1]octan-1-yl)-3-fluorobenzamide 
• 1383973-78-1 methyl 5-aminobicyclo[3.2.1]octane-1-carboxylate 
• 1396379-54-6 benzyl 5-carbamoylbicyclo[3.2.1]octan-1-ylcarbamate 
• 1383973-81-6 benzyl 5-(2-methylpyrimidin-4-ylcarbamoyl)bicyclo[3.2.1]octan-1-ylcarbamate 
• 1383971-61-6 N,N'-(bicyclo[3.2.1]octane-1,5-diyl)bis(6-methylpicolinamide) 
• 1383971-60-5 N-(5-(3-chlorobenzamido)bicyclo[3.2.1]octan-1-yl)-6-methylpicolinamide 
• 1427704-92-4 C₁₇H₂₃NO₃ 
• 54764-02-2 dimethyl bicyclo[3.3.1]nonane-1,5-dicarboxylate 

Relevant academic research and scientific papers

BICARBOCYCLIC AND TRICARBOCYCLIC ETHYNYL DERIVATIVES AND USES OF SAME

The present invention provides compounds of formula (1): where R1, R2, X. Y and n are as described herein, and pharmaceutical compositions, uses and methods comprising same.

BICYCLO[3.2.1]OCTYL AMIDE DERIVATIVES AND USES OF SAME

The present invention provides bicyclo[3.2.1]octyl amide derivatives of formula (I): wherein L, R1 and R2 are as defined herein, or a pharmaceutically acceptable salt thereof; pharmaceutical compositions and methods using the same.

PEPTIDASE INHIBITORS

The present invention relates to a series of novel compounds having the formula (I) wherein: X is NR3 or O; n is 1 or 2; A is a bicyclic carbocycle and R1 and R1 are as described herein. The compounds are useful as DPP-IV inhibitors, such as for the treatment of diabetes.

PEPTIDASE INHIBITORS

The present invention relates to a series of novel compounds having the formula: [INSERT FORMULA I] wherein A is a bicyclic carbocycle and R?1? and R?2? are independently [INSERT MOLECULE FROM CLAIM 1] The compounds are useful as DPP-IV inhibitors and for treating diabetes.

Synthesis of Bridgehead-Bridgehead Substituted Bicycloalkanes

A convenient synthetic route to several bicycloalkanes bearing substitution at both bridgehead positions is described.The two-step procedure, which involves alkylation of the monoenolates of readily available cyclohexane diesters with 1,2-dihaloethane followed by a base-inducted cyclization of the derived haloethylated product, was successfully applied to the synthesis of dimethyl bicyclooctane-1,4-dicarboxylate, dimethyl bicycloheptane-1,4-dicarboxylate and dimethyl bicyclooctane-1,5-dicarboxylate.Additionally, it was found that the two latter diesters could be obtained in quite acceptable yields in a one-pot procedure through their corresponding cyclohexyl bisenolate precursors.