106004-10-8Relevant articles and documents
BICARBOCYCLIC AND TRICARBOCYCLIC ETHYNYL DERIVATIVES AND USES OF SAME
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Page/Page column 23, (2013/03/28)
The present invention provides compounds of formula (1): where R1, R2, X. Y and n are as described herein, and pharmaceutical compositions, uses and methods comprising same.
PEPTIDASE INHIBITORS
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Page/Page column 42-43, (2010/10/19)
The present invention relates to a series of novel compounds having the formula (I) wherein: X is NR3 or O; n is 1 or 2; A is a bicyclic carbocycle and R1 and R1 are as described herein. The compounds are useful as DPP-IV inhibitors, such as for the treatment of diabetes.
Synthesis of Bridgehead-Bridgehead Substituted Bicycloalkanes
Della, Ernest W.,Tsanaktsidis, John
, p. 1705 - 1718 (2007/10/02)
A convenient synthetic route to several bicycloalkanes bearing substitution at both bridgehead positions is described.The two-step procedure, which involves alkylation of the monoenolates of readily available cyclohexane diesters with 1,2-dihaloethane followed by a base-inducted cyclization of the derived haloethylated product, was successfully applied to the synthesis of dimethyl bicyclooctane-1,4-dicarboxylate, dimethyl bicycloheptane-1,4-dicarboxylate and dimethyl bicyclooctane-1,5-dicarboxylate.Additionally, it was found that the two latter diesters could be obtained in quite acceptable yields in a one-pot procedure through their corresponding cyclohexyl bisenolate precursors.