10601-98-6

Basic information

• Product Name: Benzene, 1-(chloromethyl)-4-ethynyl-
• Synonyms: 4-ethynyl chloromethylbenzene;4-ethynylbenzyl chloride;p-ethynylbenzyl chloride
• CAS NO: 10601-98-6
• Molecular Formula: C9H7Cl
• Molecular Weight: 150.60500
• Mol File: 10601-98-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(chloromethyl)-4-ethynyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(chloromethyl)-4-ethynyl-(10601-98-6)
• EPA Substance Registry System: Benzene, 1-(chloromethyl)-4-ethynyl-(10601-98-6)

Safety Data

• Hazardous Substances Data: 10601-98-6(Hazardous Substances Data)

Upstream product

• 10602-04-7 (4-ethynylphenyl)methanol 
• 124-63-0 methanesulfonyl chloride 
• 275386-60-2 4-(hydroxymethyl)-1-(trimethylsilylethynyl)benzene 
• 873-75-6 4-bromobenzenemethanol 
• 63697-96-1 4-Ethynylbenzaldehyde 
• 10602-03-6 ethyl 4-ethynylbenzoate 

Downstream Products

• 933986-40-4 1-(4-ethynylbenzyl)-4-methylpiperazine 
• 1346617-86-4 N-[2-methyl-5-(4-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-1H-1,2,3-triazol-1-yl)phenyl]-4-(pyridine-3-yl)pyrimidin-2-amine 
• 1346617-87-5 N-[2-methyl-5-(4-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-1H-1,2,3-triazol-1-yl)phenyl]-4-phenylpyrimidin-2-amine 

Relevant articles and documents

Ionic-liquid-supported organocatalyst for the enantioselective Michael addition of ketones to nitroolefins

Ionic-liquid-supported triazole-pyrrolidine 2, for the direct asymmetric Michael reaction was successfully synthesized. The supported catalyst demonstrated good activity and high enantioselectivity in the addition of cyclohexanone to nitroolefins. Further

Lysosome-Targeting Amplifiers of Reactive Oxygen Species as Anticancer Prodrugs

Cancer cells produce elevated levels of reactive oxygen species, which has been used to design cancer specific prodrugs. Their activation relies on at least a bimolecular process, in which a prodrug reacts with ROS. However, at low micromolar concentratio

N-[2-methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine as a Scaffold for the synthesis of inhibitors of Bcr-Abl

N-[2-Methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine derivatives were synthesized and evaluated invitro for their potential use as inhibitors of Bcr-Abl. The design is based on the bioisosterism between the 1,2,3-triazole ring and the amide group. The synthesis involves a copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) as the key step, with the exclusive production of anti-(1,4)-triazole derivatives. One of the compounds obtained shows general activity similar to that of imatinib; in particular, it was observed to be more effective in decreasing the fundamental function of cdc25A phosphatases in the K-562 cell line. Willing and Abl inhibitors! N-[2-Methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine derivatives were synthesized by a copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) as a key step, with anti-(1,4)-triazole derivatives as the exclusive products. One of these compounds shows general activity similar to that of imatinib, and in particular, it is more effective in decreasing the fundamental function of cdc25A phosphatases in the K-562 cell line.