106047-28-3

Usage

Uses

Used in Organic Synthesis:
6-bromo-2,3'-bipyridine is used as a building block for the synthesis of various functionalized bipyridine derivatives, contributing to the development of new organic compounds with diverse properties and applications.
Used in Coordination Chemistry:
As a ligand, 6-bromo-2,3'-bipyridine is employed in the preparation of coordination complexes, which are essential in various fields such as catalysis, materials science, and supramolecular chemistry.
Used in Materials Science:
6-bromo-2,3'-bipyridine is utilized in the development of new materials with unique properties, such as luminescent materials, sensors, and functional polymers, by incorporating its structure into the material's composition.
Used in Catalysis:
6-broMo-2,3'-bipyridine is applied in catalysis as a ligand for the design of catalysts with improved activity, selectivity, and stability in various chemical reactions.
Used in Pharmaceutical Research:
6-bromo-2,3'-bipyridine is explored for its potential applications in the pharmaceutical industry, including the development of new drugs and drug delivery systems, due to its unique chemical properties and interactions with biological targets.
Overall, 6-bromo-2,3'-bipyridine's diverse potential uses across various scientific research and industrial applications highlight its importance as a valuable chemical intermediate.

Upstream product

• 626-55-1 3-Bromopyridine 
• 626-05-1 2,6-Dibromopyridine 
• 220565-63-9 pyridin-3-ylzinc(II) bromide 
• 1120-90-7 3-iodopyridine 
• 651358-83-7 2-bromo-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 
• 89878-14-8 3-Diethylboranylpyridine 

Relevant academic research and scientific papers

Synthesis of Bis-heteroaryls Using Grignard Reagents and Pyridylsulfonium Salts

Herein are reported ligand-coupling reactions of Grignard reagents with pyridylsulfonium salts. The method has wide functional group tolerance and enables the formation of bis-heterocycle linkages, including 2,4′-, 2,3′-, and 2,2′-bipyridines, as well as pyridines linked to pyrimidines, pyrazines, isoxazoles, and benzothiophenes. The methodology was successfully applied to the synthesis of the natural products caerulomycin A and E.

2-Pyridyl and 3-pyridylzinc bromides: direct preparation and coupling reaction

A facile synthetic approach to the direct preparation of 2-pyridyl and 3-pyridylzinc bromides has been demonstrated using Rieke zinc with 2-bromopyridine and 3-bromopyridine, respectively. A variety of different electrophiles have been coupled with the resulting organozinc reagents to give the corresponding cross-coupling products in moderate to good yields.

Palladium-catalyzed Suzuki-Miyaura coupling of pyridyl-2-boronic esters with aryl halides using highly active and air-stable phosphine chloride and oxide ligands

(Chemical Equation Presented) The palladium-catalyzed Suzuki-Miyaura coupling of pyridyl-2-boronic esters provided an efficient approach to useful biaryl building blocks containing a 2-pyridyl moiety. The convenient reaction protocol demonstrates its pote

A facile synthetic approach to the preparation of 3-pyridyl derivatives: Preparations and coupling reactions of 3-pyridylzinc and its analogues

A facile synthetic approach to the direct preparation of 3pyridylzinc bromide has been demonstrated using Rieke zinc with 3-bromopyridine in the presence of a catalytic amount of lithium chloride. A variety of different electrophiles have been coupled to give the corresponding cross-coupling products in moderate to good yields. Also, this methodology has been expanded to the preparation of the corresponding organozinc reagents of 3-bromopyridine analogues. Georg Thieme Verlag Stuttgart.

AMIDE DERIVATIVE

The present invention provides an amide derivative represented by the following general formula (1): wherein R1 represents a saturated cyclic amino group, R2 represents alkyl, halogen or haloalkyl, R3 represents hydrogen or halogen, Het 2 represents pyridyl or pyrimidinyl, and Het 1 represents a group of the formula [6], or a salt thereof, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention is useful as a BCR-ABL tyrosine kinase inhibitor.

Cross-coupling between 3-pyridylmagnesium chlorides and heteroaromatic halides

Phenyl- and thienylpyridines were prepared by Pd(0)-catalyzed cross-coupling of 3-pyridylmagnesium chlorides with iodobenzene or iodothiophene at room temperature. Starting from bromo and chloro azines and diazines, the Ni(0)-catalyzed reaction proved more suitable to allow the synthesis of pyridylpyridines, pyridylquinolines and pyridyldiazines.