651358-83-7 Usage
General Description
6-Bromopyridine-2-boronic acid pinacol ester is a chemical compound that is used in organic synthesis and medicinal chemistry. It is a boronic ester derivative of 6-bromopyridine-2-boronic acid, a compound that is often used as a building block for the synthesis of various biologically active molecules and pharmaceuticals. The pinacol ester group in the compound provides stability and solubility in organic solvents, making it a versatile reagent for Suzuki-Miyaura cross-coupling reactions. 6-Bromopyridine-2-boronic acid pinacol ester is used in the development of new drugs and agrochemicals, as well as in the study of chemical reactions and mechanisms in organic chemistry. Its unique structure and reactivity make it a valuable tool in the field of chemical synthesis.
Check Digit Verification of cas no
The CAS Registry Mumber 651358-83-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,5,1,3,5 and 8 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 651358-83:
(8*6)+(7*5)+(6*1)+(5*3)+(4*5)+(3*8)+(2*8)+(1*3)=167
167 % 10 = 7
So 651358-83-7 is a valid CAS Registry Number.
InChI:InChI=1/C11H15BBrNO2/c1-10(2)11(3,4)16-12(15-10)8-6-5-7-9(13)14-8/h5-7H,1-4H3
651358-83-7Relevant articles and documents
Synthesis of novel halopyridinylboronic acids and esters. Part 4: Halopyridin-2-yl-boronic acids and esters are stable, crystalline partners for classical Suzuki cross-coupling
Bouillon, Alexandre,Lancelot, Jean-Charles,Santos, Jana Sopkova De Oliveira,Collot, Valérie,Bovy, Philipppe R.,Rault, Sylvain
, p. 10043 - 10049 (2003)
This paper describes some methods for the synthesis and the isolation of novel 5 or 6-halopyridin-2-yl-boronic acids and esters 3, 4, 7. These compounds are prepared via a regioselective halogen-metal exchange using n-butyllithium and subsequent quenching with triisopropylborate starting from appropriate dihalopyridines. All substrates studied to date provided a single regioisomeric boronic acid or ester product. Additionally, these compounds have been found to undergo Pd-catalysed coupling with arylhalides and authorise a strategy to produce new pyridines libraries.
