10606-73-2

Basic information

• Product Name: (S)-2-chloro-2-phenylacetic acid ethyl ester
• Synonyms: (S)-2-chloro-2-phenylacetic acid ethyl ester
• CAS NO: 10606-73-2
• Molecular Weight: 198.649
• Mol File: 10606-73-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: (S)-2-chloro-2-phenylacetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-chloro-2-phenylacetic acid ethyl ester(10606-73-2)
• EPA Substance Registry System: (S)-2-chloro-2-phenylacetic acid ethyl ester(10606-73-2)

Safety Data

• Hazardous Substances Data: 10606-73-2(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 4755-72-0 Chloro-phenyl-acetic acid 
• 2912-62-1 α-chlorophenylacetyl chloride 
• 7719-09-7 thionyl chloride 
• 60-29-7 diethyl ether 
• 611-71-2 MANDELIC ACID 
• 50916-31-9 2-hydroxy-2-phenylacetyl chloride 
• 101-97-3 Ethyl 2-phenylethanoate 
• 121-44-8 triethylamine 
• 774-40-3 hydroxy-phenyl-acetic acid ethyl ester 
• 5317-66-8 ethyl α,α-dichlorophenylacetate 
• 29125-24-4 (S)-2-Chloro-2-phenylacetic acid 
• 611-71-2 (R)-Mandelic Acid 
• 62600-43-5 C₈H₆Cl₂O 

Downstream Products

• 58007-81-1 dimethylthiocarbamoylsulfanyl-phenyl-acetic acid 
• 33224-94-1 butoxy-phenyl-acetic acid 
• 96-09-3 styrene oxide 
• 4755-72-0 Chloro-phenyl-acetic acid 
• 1004-99-5 2-chloro-2-phenylethanol 
• 2048-32-0 (E)-ethyl 2,3-diphenylacrylate 
• 7042-27-5 ethyl 2,3-diphenyloxirane-2-carboxylate 
• 1762-68-1 2-amino-5-phenyl-4-thiazolidinone 
• 101450-09-3 (2-diethylamino-ethoxy)-phenyl-acetic acid ethyl ester 
• 22083-23-4 α-morpholine ethyl phenylacetate 
• 95770-77-7 4-phenyl-hexahydro-pyrido[2,1-c][1,4]oxazin-3-one 
• 95770-79-9 3-phenyl-hexahydro-pyrido[2,1-c][1,4]oxazin-4-one 
• 5595-82-4 2-methylamino-5-phenyl-selenazol-4-one 
• 5533-94-8 2-imino-3-methyl-5-phenyl-selenazolidin-4-one 

Relevant articles and documents

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Enantioselective α-Chlorination Reactions of in Situ Generated C1 Ammonium Enolates under Base-Free Conditions

The asymmetric α-chlorination of activated aryl acetic acid esters can be carried out with high levels of enantioselectivities utilizing commercially available isothiourea catalysts under base-free conditions. The reaction, which proceeds via the in situ formation of chiral C1 ammonium enolates, is best carried out under cryogenic conditions combined with a direct trapping of the activated α-chlorinated ester derivative to prevent epimerization, thus allowing for enantioselectivities of up to e.r. 99:1.

Iodobenzene Dichloride in the Esterification and Amidation of Carboxylic Acids: In-Situ Synthesis of Ph3PCl2

A novel, in-situ synthesis of dichlorotriphenylphosphorane (Ph3PCl2) is accomplished upon combining PPh3and the easily prepared hypervalent iodine reagent iodobenzene dichloride (PhICl2). The phosphorane is selectively generated in the presence of carboxylic acid or alcohol residues to rapidly produce acyl chlorides and alkyl chlorides in high yields. Addition of EtOH, PhOH, BnOH, Et2NH or CH2N2results in the direct synthesis of esters, amides and diazo ketones from carboxylic acids.

SUBSTITUTED PHENYLLUREAS AND PHENYLAMIDES AS VANILLOID RECEPTOR LIGANDS

The invention relates to substituted phenylureas and phenylamides of formula (I), to processes for the preparation thereof, to pharmaceutical compositions containing these compounds and also to the use of these compounds for preparing pharmaceutical compositions.