106064-52-2

Upstream product

• 106064-44-2 isobutyl 5-(benzyloxy)-3-hydroxypentanoate 
• 1171867-89-2 (R)-[1-(2-benzyloxy-ethyl)-but-3-enyloxy]-tert-butyldiphenyl-silane 
• 106064-50-0 5-Benzyloxy-3-(tert-butyl-diphenyl-silanyloxy)-pentanoic acid isobutyl ester 
• 106064-33-9 isobutyl 5-(benzyloxy)-3-oxopentanoate 
• 3587-60-8 Benzyloxymethyl chloride 
• 106064-51-1 5(S)-(benzyloxy)-3-((tert-butyldiphenylsilyl)oxy)pentanol 

Downstream Products

• 1313218-88-0 C₃₄H₅₀O₆Si 
• 1313218-86-8 C₄₁H₅₈O₅Si 
• 1313218-92-6 C₃₈H₅₄O₅Si 
• 1313218-90-4 C₄₀H₅₆O₆Si 
• 1313218-84-6 C₄₀H₅₄O₆Si 
• 1313218-82-4 C₃₄H₄₄O₄Si 
• 1313218-87-9 C₄₀H₆₄O₇Si₂ 
• 1313218-79-9 C₃₆H₄₈O₆Si 
• 106064-54-4 (4R,6S)-8-(benzyloxy)-6-(tert-butyldiphenylsilyloxy)oct-1-en-4-ol 
• 1171867-62-1 (S)-2-((S)-4-(benzyloxy)-2-(tert-butyldiphenylsilyloxy)butyl)-2,3-dihydropyran-4-one 
• 88818-17-1 (R)-1-phenylmethoxyoct-7-en-3-ol 
• 106064-55-5 Methanesulfonic acid (S)-1-allyl-5-benzyloxy-3-(tert-butyl-diphenyl-silanyloxy)-pentyl ester 
• 106064-57-7 [(S)-1-(2-Benzyloxy-ethyl)-3-iodo-hex-5-enyloxy]-tert-butyl-diphenyl-silane 
• 106064-59-9 [(R)-1-(2-Benzyloxy-ethyl)-hex-5-enyloxy]-tert-butyl-diphenyl-silane 

Relevant academic research and scientific papers

An asymmetric synthesis of the polyol fragment of the polyene macrolide antibiotic RK-397

A highly convergent and asymmetric synthesis of the C11-C31 polyol fragment of RK-397 as a single isomer is accomplished via a catalytic enantioselective hetero-Diels-Alder reaction and an intermolecular olefin cross-metathesis as key steps.

Substrate modification as a means of enhancing the enantioselectivity of microbial reductions of β-keto esters. An (R)- or (S )-1,3,5-trihydroxypentane synthon

The enantioselectivity of yeast-mediated reduction of 5-(benzyloxy)-3-oxopentanoate esters can be optimized by simple selection of a suitable ester alkoxy group. The resulting chiral 5-(benzyloxy)-3-hydroxypentanoates with > 95% ee can serve as either an (R)- or (S)-1,3,5-trihydroxypentane synthon for asymmetric syntheses. The synthesis of a key optically active intermediate for (S)-(-)-lipoic acid is provided as an example.