1171867-89-2Relevant academic research and scientific papers
A concise stereoselective total synthesis of diplodialide C
Pratapareddy, Bommareddy,Sreenivasulu, Reddymasu,Hatti, Islavathu,Venkata Basaveswara Rao, Mandava,Raju, Rudraraju Ramesh
, p. 1921 - 1926 (2015)
An asymmetric total synthesis of diplodialide C has been achieved starting from commercially available homoallylic alcohol. Regioselective opening of the chiral epoxide, cross-metathesis reaction, and Yamaguchi macrolactonization were used as the key step
Stereoselective synthesis and biological evaluation of (R)-rugulactone, (6R)-((4R)-hydroxy-6-phenyl-hex-2-enyl)-5,6-dihydro-pyran-2-one and its 4S epimer
Reddy, D. Kumar,Shekhar,Prabhakar,Chinna Babu,Siddhardha,Murthy,Venkateswarlu
experimental part, p. 4657 - 4663 (2010/10/19)
A simple and highly efficient synthetic route has been developed for synthesis of (R)-rugulactone (1a), (6R)-((4R)-hydroxy-6-phenyl-hex-2-enyl)-5,6- dihydro-pyran-2-one (1b) and its 4S epimer 1c by employing proline-catalyzed α-aminooxylation, Sharpless epoxidation, Mitsunobu reaction as chirality introuducing steps. The antibacterial and antifungal activity of the compounds 1a, 1b and 1c were evaluated. 1a and 1b showed better antibacterial activity against Pseudomonas aeroginosa (MIC =12.5 μg/ml for 1a, 25 μg/ml for 1b) Klebsiella pneumonia (MIC =25 μg/ml for 1a). Compounds (1a, 1b, 1c) exhibited good to moderate antifungal activity.
Stereoselective first total synthesis of (R)-rugulactone
Reddy, D. Kumar,Shekhar,Reddy, T. Srikhanth,Reddy, S. Purushotham,Venkateswarlu
experimental part, p. 2315 - 2319 (2010/03/04)
A simple and highly efficient stereoselective synthetic route has been developed for the synthesis of (R)-rugulactone, a 6-arylalkyl-5,6-dihydro-2H-pyran-2-one, from readily available substrates such as 1,3-propanediol and 3-phenyl-1-propanal employing Ke
An asymmetric synthesis of the polyol fragment of the polyene macrolide antibiotic RK-397
Fu, Fan,Loh, Teck-Peng
scheme or table, p. 3530 - 3533 (2009/10/26)
A highly convergent and asymmetric synthesis of the C11-C31 polyol fragment of RK-397 as a single isomer is accomplished via a catalytic enantioselective hetero-Diels-Alder reaction and an intermolecular olefin cross-metathesis as key steps.
