106064-60-2

Basic information

• Product Name: Pentanoic acid, 3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-5-hydroxy-, methyl ester, (R)-
• CAS NO: 106064-60-2
• Molecular Formula: C22H30O4Si
• Molecular Weight: 386.563
• Mol File: 106064-60-2.mol

Chemical Properties

• CAS DataBase Reference: Pentanoic acid, 3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-5-hydroxy-, methyl ester, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pentanoic acid, 3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-5-hydroxy-, methyl ester, (R)-(106064-60-2)
• EPA Substance Registry System: Pentanoic acid, 3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-5-hydroxy-, methyl ester, (R)-(106064-60-2)

Safety Data

• Hazardous Substances Data: 106064-60-2(Hazardous Substances Data)

Upstream product

• 7250-55-7 dimethyl 3-hydroxypentanedioate 
• 87118-53-4 (R)-3-hydroxypentanedioic acid monomethyl ester 
• 127533-62-4 methyl 4-(1,3-dithian-2-yl)-3-oxobutanoate 
• 81114-98-9 Chan's diene 
• 186581-53-3 diazomethane 
• 106064-61-3 (R)-3-[(tert-butyldiphenylsilyl)oxy]pentanoic acid lactone 
• 127533-69-1 methyl (R)-3-tert-butyldiphenylsilyloxy-5-oxopentanoate 
• 87118-55-6 (R)-((3-tert-butyldiphenylsillyl)oxy)pentanedioic acid monomethyl ester 
• 127533-64-6 (S)-4-[1,3]Dithian-2-yl-3-hydroxy-butyric acid methyl ester 
• 127533-68-0 methyl (S)-3-(t-butyldiphenylsiloxy)-4-(1,3-dithian-2-yl)-butanoate 

Downstream Products

• 127533-69-1 methyl (R)-3-tert-butyldiphenylsilyloxy-5-oxopentanoate 
• 106064-61-3 (R)-3-[(tert-butyldiphenylsilyl)oxy]pentanoic acid lactone 

Relevant articles and documents

Enantiospecific total synthesis of a novel arachidonic acid metabolite 3-hydroxyeicosatetraenoic acid

The enantiomers R- and S-3-hydroxyeicosatetraenoic acid 11a, 11b were synthesized from coupling of a chiral aldehyde 7 with a Wittig salt 4, which were derived from 2-deoxy-D-ribose and arachidonic acid, respectively.

Substrate modification as a means of enhancing the enantioselectivity of microbial reductions of β-keto esters. An (R)- or (S )-1,3,5-trihydroxypentane synthon

The enantioselectivity of yeast-mediated reduction of 5-(benzyloxy)-3-oxopentanoate esters can be optimized by simple selection of a suitable ester alkoxy group. The resulting chiral 5-(benzyloxy)-3-hydroxypentanoates with > 95% ee can serve as either an (R)- or (S)-1,3,5-trihydroxypentane synthon for asymmetric syntheses. The synthesis of a key optically active intermediate for (S)-(-)-lipoic acid is provided as an example.