106064-61-3

Basic information

• Product Name: 2H-Pyran-2-one, 4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]tetrahydro-, (R)-
• CAS NO: 106064-61-3
• Molecular Formula: C21H26O3Si
• Molecular Weight: 354.521
• Mol File: 106064-61-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2H-Pyran-2-one, 4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]tetrahydro-, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Pyran-2-one, 4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]tetrahydro-, (R)-(106064-61-3)
• EPA Substance Registry System: 2H-Pyran-2-one, 4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]tetrahydro-, (R)-(106064-61-3)

Safety Data

• Hazardous Substances Data: 106064-61-3(Hazardous Substances Data)

Upstream product

• 87118-55-6 (R)-((3-tert-butyldiphenylsillyl)oxy)pentanedioic acid monomethyl ester 
• 87118-53-4 (R)-3-hydroxypentanedioic acid monomethyl ester 
• 7250-55-7 dimethyl 3-hydroxypentanedioate 
• 17676-20-9 methyl 2-deoxy-β-D-erythro-pentopyranoside 
• 157394-79-1 tert-Butyl-((2R,4R)-2-methoxy-tetrahydro-pyran-4-yloxy)-diphenyl-silane 
• 158719-05-2 (3R,4S,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-3-ol 
• 158718-95-7 2(R)-methoxy-4(S)-<(tert-butyldiphenylsilyl)oxy>-2,3-dihydro-4H-pyran 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 127533-64-6 (S)-4-[1,3]Dithian-2-yl-3-hydroxy-butyric acid methyl ester 
• 127533-62-4 methyl 4-(1,3-dithian-2-yl)-3-oxobutanoate 
• 127533-68-0 methyl (S)-3-(t-butyldiphenylsiloxy)-4-(1,3-dithian-2-yl)-butanoate 
• 106064-60-2 (R)-3-[(tert-butyldiphenylsilyl)oxy]pentanoic acid methyl ester 

Downstream Products

• 157394-84-8 (8E,10E,14Z)-(3R,12R)-3,12-Bis-(tert-butyl-diphenyl-silanyloxy)-1-hydroxy-icosa-8,10,14-trien-6-yn-5-one 
• 106064-60-2 (R)-3-[(tert-butyldiphenylsilyl)oxy]pentanoic acid methyl ester 
• 127533-69-1 methyl (R)-3-tert-butyldiphenylsilyloxy-5-oxopentanoate 

Relevant articles and documents

Total Synthesis of the Ethanol Inducible, Proinflammatory Autacoid 3(S)-Hydroxy-Leukotriene B4 (3-OH-LTB4) and Analogues

3(S)-Hydroxy-Leukotriene B4 (1a), its 3(R)-epimer 1b, and 14,15-acetylenic analogue were efficiently prepared via chelation-controlled reduction of ketone 12, obtained by acetylide addition to chiral β-hydroxylactones 7/9. - Key Words: eicosanoid, chelati

Substrate modification as a means of enhancing the enantioselectivity of microbial reductions of β-keto esters. An (R)- or (S )-1,3,5-trihydroxypentane synthon

The enantioselectivity of yeast-mediated reduction of 5-(benzyloxy)-3-oxopentanoate esters can be optimized by simple selection of a suitable ester alkoxy group. The resulting chiral 5-(benzyloxy)-3-hydroxypentanoates with > 95% ee can serve as either an (R)- or (S)-1,3,5-trihydroxypentane synthon for asymmetric syntheses. The synthesis of a key optically active intermediate for (S)-(-)-lipoic acid is provided as an example.