106070-45-5

Upstream product

• 13344-76-8 (S)-(+)-2-fluorophenylacetaldehyde 
• 98-89-5 Cyclohexanecarboxylic acid 
• 20780-54-5 (S)-styrene oxide 
• 20780-53-4 (R)-Styrene oxide 
• 864658-42-4 2,2-dimethylpropanoicphenylacetic anhydride 
• 103-82-2 phenylacetic acid 
• 1615693-29-2 C₁₆H₂₀FNO₃ 
• 311310-12-0 (S)-4-iso-propyl-3-(2'-phenylacetyl)-5,5-dimethyloxazolidin-2-one 
• 126308-85-8 (S)-4-((S)-Fluoro-phenyl-methyl)-2,2-dimethyl-[1,3]dioxolane 
• 126308-87-0 (2S,3S)-3-Fluoro-3-phenyl-propane-1,2-diol 
• 86525-61-3 (S)-3-Fluoro-3-phenyl-propane-1,2-diol 
• 10606-72-1 (R)-mandelic acid ethyl ester 

Downstream Products

• 13344-76-8 (S)-(+)-2-fluorophenylacetaldehyde 
• 13344-76-8 (R)-(-)-2-fluorophenylacetaldehyde 
• 247039-05-0 (R_S)-(+)-2-[N-(p-toluenesulfinamido)]-3-(S)-fluoro-3-phenylpropionitrile 

Relevant academic research and scientific papers

Metal-Free and User-Friendly Regioselective Hydroxyfluorination of Olefins

A simple, user-friendly, metal-free protocol for the regioselective anti-Markovnikov hydrofluorination of olefins using readily available and inexpensive reagents has been developed. This new approach displays a broader scope than previously reported methodologies and has been applied to the late-stage fluorination of a complex molecule, giving rise to a fluorosteroid derivative. The stereochemistry of the process has also been studied in some detail.

Stereoselective α-fluorination of N -acyloxazolidinones at room temperature within 1 h

A direct α-fluorination of N-acyloxazolidinones based on the unique reactivity of group IVa metal enolates has been developed. The reaction is an experimentally simple, low-cost, quick, and energy-efficient alternative for asymmetric α-fluorination of N-acyloxazolidinones. Preliminary studies have shown compatibility with alkyl, alkenyl, and alkynyl, aromatic, and several heteroaromatic substituents. High diastereoselectivities have been achieved with most substrates tested, and the reaction is typically complete within 1 h at ambient temperature.

Preparation of Chiral Fluorine Compounds from (2S,3S)-3-Phenylglycidol

Some potentially useful chiral fluorine compounds have been synthesized starting from (2S,3S)-3-phenylglycidol.

FLUORINATION OF HYDROXYESTERS WITH N,N-DIETHYL-1,1,2,3,3,3-HEXAFLUOROPROPYLAMINE

The reaction of 1,1,2,3,3,3-hexafluoropropyldiethylamine (PPDA) with hydroxy esters having Ph-C(H)(OH)-groups gave their corresponding secondary fluorides.Fluorination of (R)-(-)-mandelic acid ethylester (29D -106.46) gave ethyl (