106079-12-3

Basic information

• Product Name: Cyclobutanecarboxaldehyde, 1-(4-chlorophenyl)-
• CAS NO: 106079-12-3
• Molecular Formula: C11H11ClO
• Molecular Weight: 194.661
• Mol File: 106079-12-3.mol

Chemical Properties

• CAS DataBase Reference: Cyclobutanecarboxaldehyde, 1-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclobutanecarboxaldehyde, 1-(4-chlorophenyl)-(106079-12-3)
• EPA Substance Registry System: Cyclobutanecarboxaldehyde, 1-(4-chlorophenyl)-(106079-12-3)

Safety Data

• Hazardous Substances Data: 106079-12-3(Hazardous Substances Data)

Upstream product

• 28049-61-8 1-(4-chlorophenyl)cyclobutanecarbonitrile 
• 4426-11-3 cyclobutanecarbonitrile 
• 352-33-0 1-Chloro-4-fluorobenzene 

Downstream Products

• 1359840-94-0 tert-butyl {2-[1-(4-chlorophenyl)cyclobutyl]-2-(3-cyanophenyl)ethyl}carbamate 
• 1359840-93-9 3-{2-amino-1-[1-(4-chlorophenyl)cyclobutyl]ethyl}benzonitrile 
• 1359840-92-8 3-{1-[1-(4-chlorophenyl)cyclobutyl]-2-nitroethyl}benzonitrile 
• 1359840-90-6 1-chloro-4-{1-[(E)-2-nitroethenyl]cyclobutyl}benzene 
• 1359840-32-6 tert-butyl {2-[1-(4-chlorophenyl)cyclobutyl]-2-[3-({methyl[(1-methyl-1H-pyrazol-4-yl)sulfonyl]amino}methyl)phenyl]ethyl}carbamate 
• 1359840-96-2 tert-butyl (2-[1-(4-chlorophenyl)cyclobutyl]-2-{3-[(methylamino)methyl]phenyl}ethyl)carbamate 
• 1359840-95-1 tert-butyl {2-[1-(4-chlorophenyl)cyclobutyl]-2-(3-formylphenyl)ethyl}carbamate 
• 1240048-89-8 1-[1-(4-chlorophenyl)cyclobutyl]-2,3,4,9-tetrahydro-1H-b-carboline 
• 1240048-69-4 6-(1-(4-chlorophenyl)cyclobutyl)-5-nitropiperidin-2-one 
• 229639-54-7 (R)-(+)-N-{1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N-methylamine 
• 229639-57-0 (S)-(-)-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine 
• 229639-56-9 (R)-N-{1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutyl}amine 
• 858645-29-1 (R)-N-(1-(4-chlorophenyl)cyclobutanemethylene)-t-butanesulfinamide 
• 259729-89-0 [1-[1-(4-Chloro-phenyl)-cyclobutyl]-meth-(E)-ylidene]-methyl-amine 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE AS INHIBITORS OF THE GLYCINE TRANSPORTER 1

The present invention relates to heterocyclic compounds of the formula (I) or a physiologically tolerated salt thereof. The present invention also relates to pharmaceutical compositions comprising such heterocyclic compounds, and the use of such heterocyclic compounds for the manufacture of a medicament for inhibiting the glycine transporter GIyT1.

First asymmetric synthesis of (R)-desmethylsibutramine

A catalytic enantioselective addition of iBuLi to aldimine 3 derived from methyl amine and 1-(4-chlorophenyl) cyclobutanecarboxaldehyde is used as the key step in the asymmetric synthesis of (R)-desmethylsibutramine, a single enantiomer version of a pharmacologically active metabolite of anti-obesity drug sibutramine (Meridia).

First application of tunable alkyl or aryl sulfinamides to the stereoselective synthesis of a chiral amine: asymmetric synthesis of (R)-didesmethylsibutramine ((R)-DDMS) using (R)-triethylmethylsulfinamide ((R)-TESA).

A highly diastereoselective addition of i-BuLi to a triethylmethylsulfinamide derived aldimine was used as the key step in the first asymmetric synthesis of (R)-didesmethylsibutramine, a metabolite of sibutramine for the potential treatment of CNS disorders. [reaction: see text]

Arylcyclobutylmethylamines

Compounds of formula I STR1 and pharmaceutically acceptable salts thereof; in which R1 and R2, which are the same or different, are H or an optionally substituted hydrocarbon group or R1 and R2 together with the nitrogen atom to which they are attached form an optionally substituted heterocyclic ring; R3 is an optionally substituted aromatic hydrocarbon group; and R4 is a hydrocarbon group containing at least one substituent selected from the group consisting of hydroxy and acylated derivatives thereof, optionally substituted alkoxy groups, optionally substituted cycloalkyloxy groups, optionally substituted alkylenedioxy groups, oxo and groups of formula S(O)p R5 in which p is 0, 1 or 2 and R5 is an alkyl group, said hydrocarbon group being optionally substituted by additional substituents, are useful in the treatment of depression.