1060814-88-1

Basic information

• Product Name: ethyl 2-(5-bromopyridin-2-yl)acetate
• Synonyms: ethyl 2-(5-bromopyridin-2-yl)acetate;Ethyl 5-broMopyridine-2-a...;Ethyl 5-broMopyridine-2-acetate;2-Pyridineacetic acid, 5-bromo-, ethyl ester;Ethyl 2-(5-bromo-2-pyridyl)acetate
• CAS NO: 1060814-88-1
• Molecular Formula: C₉H₁₀BrNO₂
• Molecular Weight: 244
• Mol File: 1060814-88-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 282.4±25.0 °C(Predicted)
• Appearance: /
• Density: 1.451±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 2.05±0.22(Predicted)
• CAS DataBase Reference: ethyl 2-(5-bromopyridin-2-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(5-bromopyridin-2-yl)acetate(1060814-88-1)
• EPA Substance Registry System: ethyl 2-(5-bromopyridin-2-yl)acetate(1060814-88-1)

Safety Data

• Hazardous Substances Data: 1060814-88-1(Hazardous Substances Data)

Usage

General Description

Ethyl 2-(5-bromopyridin-2-yl)acetate is a chemical compound with the molecular formula C10H11BrNO2. It is a ester derivative that contains a brominated pyridine ring and an acetate group. ethyl 2-(5-bromopyridin-2-yl)acetate is commonly used in organic synthesis and pharmaceutical research, where it can be utilized as a building block in the production of various drug compounds. It is important to handle and store ethyl 2-(5-bromopyridin-2-yl)acetate with care, as it may be hazardous if not properly handled. Additionally, it is important to follow proper safety precautions and utilize appropriate protective equipment when working with this compound.

Upstream product

• 3430-13-5 5-bromo-2-methylpyridine 
• 105-58-8 Diethyl carbonate 
• 624-28-2 2,5-dibromopyridine 
• 105-36-2 ethyl bromoacetate 
• 223463-13-6 2-iodo-5-bromopyridine 
• 105-53-3 diethyl malonate 
• 1215098-80-8 diethyl 2-(5-bromopyridin-2-yl)malonate 

Downstream Products

• 99986-02-4 ethyl 2-(5-ethylpyridin-2-yl)acetate 
• 55899-30-4 ethyl 6-bromopyrazolo[1,5-a]pyridine-3-carboxylate 

Relevant articles and documents

Dual Gold/Silver Catalysis: Indolizines from 2-Substituted Pyridine Derivatives via a Tandem C(sp3)–H Alkynylation/Iminoauration

A dual gold/silver-catalyzed cascade C(sp3)–H alkynylation/iminoauration of 2-substituted pyridines with hypervalent iodine(III) reagents for the synthesis of indolizines is described. This novel reaction involves the formation of an alkynyl Au(III) species, a dual gold/silver-catalyzed C(sp3)–H functionalization, and a subsequent iminoauration process. A number of indolizines bearing diverse functionalities were prepared in good to excellent yield. Furthermore, a gram-scale reaction was efficiently conducted.

5-MEMBERED AND BICYCLIC HETEROCYCLIC AMIDES AS INHIBITORS OF ROCK

The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.

IMIDAZO-PYRAZINE DERIVATIVES USEFUL AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS

A compound of Formula II or a pharmaceutically acceptable salt thereof, are capable of modulating the body's production of cyclic guanosine monophosphate ("cGMP") and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of Formula II, or a pharmaceutically acceptable salt thereof, for their use in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of Formula II or a pharmaceutically acceptable salt thereof.