1061214-06-9

Basic information

• Product Name: Celecoxib iMpurity-G
• Synonyms: Celecoxib iMpurity-G;(E)-4-(2-(1-(p-tolyl)ethylidene)hydrazinyl)benzenesulfonamide;4-(2-(1-p-tolylethylidene)hydrazinyl)benzenesulfonamide
• CAS NO: 1061214-06-9
• Molecular Formula: C₁₅H₁₇N₃O₂S
• Molecular Weight: 303.38
• Mol File: 1061214-06-9.mol

Chemical Properties

• Melting Point: 224-226 °C(Solv: ethanol (64-17-5))
• Boiling Point: 484.9±55.0 °C(Predicted)
• Appearance: /
• Density: 1.25±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 10.53±0.12(Predicted)
• CAS DataBase Reference: Celecoxib iMpurity-G(CAS DataBase Reference)
• NIST Chemistry Reference: Celecoxib iMpurity-G(1061214-06-9)
• EPA Substance Registry System: Celecoxib iMpurity-G(1061214-06-9)

Safety Data

• Hazardous Substances Data: 1061214-06-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Celecoxib iMpurity-G is used as an impurity in the production of Celecoxib, a selective COX-2 inhibitor, for its anti-inflammatory properties. It helps in the treatment of various inflammatory conditions by reducing the hormones responsible for inflammation and pain in the body.
Used in Treatment of Familial Adenomatous Polyposis:
Celecoxib iMpurity-G is used in the treatment of familial adenomatous polyposis, a condition characterized by the development of numerous polyps in the colon and rectum. It helps in reducing the inflammation and pain associated with this condition.
Celecoxib iMpurity-G is also used in the development and testing of new drugs and therapies targeting COX-2 enzymes, contributing to the advancement of pharmaceutical research and development.

Upstream product

• 17852-52-7 4-hydrazinobenzene-1-sulfonamide hydrochloride 
• 122-00-9 para-methylacetophenone 
• 4392-54-5 4-aminosulfonylphenylhydrazine 

Downstream Products

• 1135952-94-1 C₂₀H₂₀N₄O₃S 
• 1448798-93-3 N-[(dimethylamino)methylidene]-4-{2-[1-(4-methylphenyl)ethylidene]hydrazino}benzenesulfonamide 
• 1443022-06-7 4-(4-(5-(4-chlorophenyl)-2-(4-methoxyphenyl)-1H-pyrrol-3-yl)-3-p-tolyl-1H-pyrazol-1-yl)benzenesulfonamide 
• 1443022-05-6 4-(4-(5-(4-chlorophenyl)-2-(4-fluorophenyl)-1H-pyrrol-3-yl)-3-p-tolyl-1H-pyrazol-1-yl)benzenesulfonamide 
• 1443021-98-4 4-(4-(4-(4-chlorophenyl)-1-(4-methoxyphenyl)-1,4-dioxobutan-2-yl)-3-p-tolyl-1H-pyrazol-1-yl)benzenesulfonamide 
• 1443021-97-3 4-(4-(4-(4-chlorophenyl)-1-(4-fluorophenyl)-1,4-dioxobutan-2-yl)-3-p-tolyl-1H-pyrazol-1-yl)benzenesulfonamide 
• 1443021-85-9 4-(4-((4-chlorophenylimino)methyl)-3-p-tolyl-1H-pyrazol-1-yl)benzenesulfonamide 
• 1443021-84-8 4-(4-((4-methoxyphenylimino)methyl)-3-p-tolyl-1H-pyrazol-1-yl)benzenesulfonamide 
• 1443021-83-7 4-(4-((phenylimino)methyl)-3-p-tolyl-1H-pyrazol-1-yl)benzenesulfonamide 
• 1293980-97-8 1-[4-(aminosulfonyl)phenyl]-3-(4-methylphenyl)-1H-pyrazole-4-carbothioamide 
• 1135953-23-9 4-(4-cyano-3-(p-tolyl)-1H-pyrazol-1-yl)benzenesulfonamide 
• 1293980-84-3 1-[4-(aminosulfonyl)phenyl]-3-(4-methylphenyl)-1H-pyrazole-4-carboxylic acid 
• 1135953-00-2 4-(4-formyl-3-(p-tolyl)-1Hpyrazol-1-yl)benzenesulfonamide 

Relevant articles and documents

Pyrazole-4-carboxylic Acids from Vanadium-catalyzed Chemical Transformation of Pyrazole-4-carbaldehydes

The conversion of aldehydes into carboxylic acids using oxidizing agents is a common protocol in transformation chemistry. An efficient oxidation strategy of transformation of pyrazole-4-aldehydes to the corresponding acids using vanadium catalysts in the presence of 30% H2O2 as an oxidant is described. The catalytic technology was successfully applied to a range of various 4-formylpyrazoles, and plausible mechanism is also discussed.

Pyrazolylbenzo[d]imidazoles as new potent and selective inhibitors of carbonic anhydrase isoforms hCA IX and XII

Novel pyrazolylbenzo[d]imidazole derivatives (2a-2f) were designed, synthesized and evaluated against four human carbonic anhydrase isoforms belonging to α family comprising of two cytosolic isoforms hCA I and II as well as two transmembrane tumor associated isoforms hCA IX and XII. Starting from these derivatives that showed high potency but low selectivity in favor of tumor associated isoforms hCA IX and XII, we investigated the impact of removing the sulfonamide group. Thus, analogs 3a-3f without sulfonamide moiety were synthesized and biological assay revealed a good activity as well as an excellent selectivity as inhibitors for tumor associated hCA IX and hCA XII and the same was analyzed by molecular docking studies.

A Mild TEMPO-Catalyzed Aerobic Oxidative Conversion of Aldehydes into Nitriles

An efficient method to prepare nitriles from aldehydes using hexamethyldisilazane (HMDS) as the nitrogen source has been developed. The reactions were performed with 2,2,6,6-tetramethylpiperidine l-oxyl (TEMPO) as the catalyst, NaNO2 or TBN as the co-catalyst, and molecular oxygen as the terminal oxidant under mild conditions. A variety of aromatic, heteroaromatic, aliphatic and allylic aldehydes could be converted into their corresponding nitriles in good to excellent yields.

Synthesis of 4-(2-substituted hydrazinyl)benzenesulfonamides and their carbonic anhydrase inhibitory effects

In this study, 4-(2-substituted hydrazinyl)benzenesulfonamides were synthesized by microwave irradiation and their chemical structures were confirmed by 1H NMR, 13CNMR, and HRMS. Ketones used were: Acetophenone (S1), 4-methylacetophe

Synthesis of novel 1,3,4-trisubstituted pyrazoles as anti-inflammatory and analgesic agents

Some novel 1,3,4-trisubstituted pyrazoles were synthesized and screened for their anti-inflammatory and analgesic activities as well as their ulcerogenic liability. They showed anti-inflammatory and analgesic activities with better GIT tolerance than the standard drug phenylbutazone. In addition, IC 50 values for 5e and 8e were recorded. Compound 5e was found to be the most active one as anti-inflammatory and analgesic agent. On the other hand, COX-1/COX-2 isozyme selectivity was also done which showed equal inhibition to both isoforms.

Synthesis and biological evaluation of some 4-functionalized-pyrazoles as antimicrobial agents

1,3-Diaryl-4-formylpyrazoles 8 bearing benzenesulfonamide moiety at position-1 were synthesized as important intermediates following Vilsmeier-Haack strategy. Aldehyde moiety of 4-formylpyrazole was then converted into carboxylic acid 9, cyano 10 and carbothioamide 11 using established procedures. Out of these 4-functionalized pyrazoles, pyrazole-4-carboxylic acids 9 and carbothioamides 11 were evaluated for their in vitro antibacterial activity against four pathogenic bacterial strains namely, Staphylococcus aureus, Bacillus subtilis (Gram-positive), Escherichia coli, Pseudomonas aeruginosa (Gram-negative), and in vitro antifungal activity against two pathogenic fungal strains namely, Aspergillus niger and Aspergillus flavus. Three tested compounds, 9e, 11b and 11f exhibited moderate antibacterial activity against Gram-positive bacteria and 9g showed moderate antifungal activity against the tested fungi. However, none of the compounds showed any activity against Gram-negative bacteria.