61348-47-8

Basic information

• Product Name: 2-(5-ISOXAZOLYL)PHENOL
• Synonyms: 5-(2-HYDROXYPHENYL)ISOXAZOLE;2-(ISOXAZOL-5-YL)PHENOL;2-(5-ISOXAZOLYL)PHENOL;2-(5-ISOXAZOLYL)PHENOL 98%;2-(5-Isoxazole)-Phenol;Phenol, 2-(5-isoxazolyl)- (9CI);2-(Isoxazole-5-yl)phenol;6-(2H-1,2-oxazol-5-ylidene)cyclohexa-2,4-dien-1-one
• CAS NO: 61348-47-8
• Molecular Formula: C₉H₇NO₂
• Molecular Weight: 161.16
• Product Categories: OXAZOLE;Building Blocks;Heterocyclic Building Blocks;Isoxazoles
• Mol File: 61348-47-8.mol

Chemical Properties

• Melting Point: 183-186°C
• Boiling Point: 320.88°C at 760 mmHg
• Flash Point: 147.863°C
• Appearance: /
• Density: 1.248g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.582
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-(5-ISOXAZOLYL)PHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-ISOXAZOLYL)PHENOL(61348-47-8)
• EPA Substance Registry System: 2-(5-ISOXAZOLYL)PHENOL(61348-47-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 61348-47-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(5-ISOXAZOLYL)PHENOL is used as a pharmaceutical compound for its potential to combat various medical conditions due to its antimicrobial, antioxidant, and anti-inflammatory properties. Its multifaceted biological activity makes it a candidate for drug development, particularly in the treatment of infections, oxidative stress-related disorders, and inflammatory conditions.
Used in Organic Synthesis:
In the realm of organic chemistry, 2-(5-ISOXAZOLYL)PHENOL is used as a synthetic intermediate for the creation of other organic compounds. Its structural features allow it to be a valuable building block in the synthesis of complex organic molecules, which can be applied across different industries, including but not limited to pharmaceuticals, agrochemicals, and materials science.
Used in Antimicrobial Applications:
2-(5-ISOXAZOLYL)PHENOL is utilized as an antimicrobial agent, leveraging its ability to inhibit the growth of microorganisms. This property is particularly useful in the development of new antibiotics or antifungal agents, contributing to the fight against drug-resistant pathogens and the improvement of public health.
Used in Antioxidant Formulations:
The antioxidant properties of 2-(5-ISOXAZOLYL)PHENOL make it suitable for use in formulations aimed at preventing or reducing oxidative damage. It can be incorporated into health supplements, skincare products, or other applications where protection against oxidative stress is desired.
Used in Anti-Inflammatory Medicines:
Given its anti-inflammatory properties, 2-(5-ISOXAZOLYL)PHENOL is used in the development of anti-inflammatory drugs. It may help in managing inflammation-related conditions, providing relief and potentially reducing the reliance on traditional nonsteroidal anti-inflammatory drugs (NSAIDs) with known side effects.

InChI:InChI=1/C9H7NO2/c11-8-4-2-1-3-7(8)9-5-6-10-12-9/h1-6,11H

Upstream product

• 491-38-3 1-benzopyran-4(4H)-one 
• 39079-62-4 chromone-3-carboxylic acid 
• 67-56-1 methanol 
• 14386-66-4 2-(formylacetyl)phenol 
• 1776-33-6 3-Diaethylamino-1-<2-hydroxy-phenyl>-propenon 
• 1776-08-5 (E)-3-(dimethylamino)-1-(2-hydroxyphenyl)prop-2-en-1-one 
• 118-93-4 o-hydroxyacetophenone 
• 582-24-1 1-phenyl-2-hydroxyethanone 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 52147-97-4 trans 2-phenylethenesulfonyl chloride 
• 84200-61-3 4-Oxo-4H-<1>benzopyran-3-sulfinsaeure 
• 66665-80-3 2-hydroxy-ω-formylacetophenone aldoxime 
• 106129-86-6 1-(2-hydroxyphenyl)-3-dimethylaminoprop-2-enone 

Downstream Products

• 6722-08-3 2-Imino-4-hydroxy-cumarin 
• 10523-47-4 3-(2-hydroxyphenyl)-3-oxopropanenitrile 
• 1380732-85-3 1-(2,2-dimethylbenzo[d][1,3]dioxol-5-yl)-2-(2-(isoxazol-5-yl)phenoxy)ethanone 
• 10523-64-5 2-(5-amino-1H-pyrazol-3-yl)phenol 
• 647014-03-7 E-[4-(2-(5-isoxazolyl)phenyloxy)piperidin-1-ylsulphonyl]-2-phenylethene 
• 38518-76-2 2-amino-4H-1-benzopyran-4-one 
• 65479-00-7 1-acetoxy-2-isoxazol-5-yl-benzene 

Relevant articles and documents

CuI/Cu(OSO2CF3)2 catalysed convenient approach to dichromenopyridines and triazole-thiazole appended chromone derivatives

A variety of new pentacyclic dichromenopyridines have been synthesized from 2-amino chromone and O-propargyloxy salicilaldehydes through intramolecular Povarov reaction using CuI/Cu(OSO2CF3)2 as a Lewis acid catalyst. The

Synthesis, antimicrobial and antiproliferative activities, molecular docking, and computational studies of novel heterocycles

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Zn(OTf)2-Catalyzed Formal [3 + 3] Cascade Annulation of Propargylic Alcohols with 2-Aminochromones: Accessing the Chromeno[2,3- b]pyridines

A Zn(OTf)2-catalyzed formal [3 + 3] cascade annulation strategy for the synthesis of functionalized chromeno[2,3-b]pyridines has been developed using propargylic alcohols and 2-aminochromones as the substrates. The protocol provides a convenien

Chromenone-rhodamine conjugate for naked eye detection of Al3+ and Hg2+ ions in semi aqueous medium

Chromenone-rhodamine conjugate 1 has been synthesized and its metal ion binding properties have been studied in CH3CN/water (3:1, v/v; 10?mM HEPES buffer; pH?=?6.85). Compound 1 senses multiple metal ions such as Al3+ and Hg2+/

Synthesis of unsymmetrical 4-oxo-2-vinyl-4H-chromene-3-carbonitrile dyes via Knoevenagel reaction

New 4-oxo-2-vinyl-4H-chromene-3-carbonitrile derivatives have been synthesized by the Knoevenagel reaction of 2-methyl-4-oxo-4H-chromene-3-carbonitrile with aromatic and heteroaromatic aldehydes. Spectral properties of the obtained compounds have been studied.

A Convenient and Practical Synthesis of Aminopyrazoles

A selective methodology for preparing highly substituted aminopyrazoles has been demonstrated. Starting with an acetophenol core, the corresponding substituted isoxazole is prepared in two steps. The isoxazole is transformed into a benzopyran. Alkylation

Synthesis of new hybrid heterocyclic compounds having 1,2,3-triazole and isoxazole via click chemistry

A simple and highly efficient method for the regioselective synthesis of isoxazolyl-1,4-disubstituted-1,2,3-triazoles 6a-l in good to excellent yields from terminal alkynes having isoxazole scaffold 4a-c and various azides through Cu(I)-catalyzed 1,3-dipolar cycloaddition is described. The reaction proceeds smoothly in 1:1 mixture of t-BuOH and water at RT. The structures of all newly synthesized hybrid heterocycles are established on the basis of spectral data ir, 1H nmr, mass, and elemental analysis.

Facile syntheses of 2-substituted 3-cyanochromones

A simple and general route to 3-cyanochromones containing various substituents on position 2 of the ring is developed. The method is based on condensation of 3-(2-hydroxyphenyl)-3-oxopropionitrile with acid chlorides or anhydrides in pyridine at room temp

Synthesis of 2,2′-diaminobischromones using a modified procedure for the rearrangement of 5-(2-hydroxyphenyl)isoxazole to 2-aminochromone

A modified procedure for the rearrangement of 5-(2-hydroxyphenyl)isoxazoles 6a-e to 2-aminochromones 8a-e was developed and this procedure was utilised in the synthesis of hitherto unreported bischromones 3a-c. The isoxazoles 6a-e were prepared regioselec

A rapid and facile synthesis of isoxazolyl and pyrazolyl phenols from enaminoketones using montmorillonite under heterogeneous catalytic conditions

A number of isoxazolyl and pyrazolyl phenols (4a-f and 5a-d) have been synthesized from 1-(2-hydroxyaryl)-3-dimethylamino-2-propen-1-ones 3a-f using montmorillonite as solid acid support.