1061330-08-2Relevant articles and documents
Stereodivergent synthesis of enantioenriched 4-hydroxy-2-cyclopentenones
Singh, Gurpreet,Meyer, Angelica,Aube, Jeffrey
, p. 452 - 458 (2014)
Protected 4-hydroxycyclopentenones (4-HCPs) constitute an important class of intermediates in chemical synthesis. A route to this class of compound has been developed. Key steps include Noyori reduction (which establishes the stereochemistry of the produc
Improved synthesis of the epoxy isoprostane phospholipid PEIPC and its reactivity with amines
Jung, Michael E.,Berliner, Judith A.,Koroniak, Lukasz,Gugiu, B. Gabriel,Watson, Andrew D.
supporting information; experimental part, p. 4207 - 4209 (2009/05/30)
(Chemical Equation Presented) An improved synthesis of the naturally occurring hydroxy ketone 1-palmitoyl-2-(5,6)-epoxyisoprostane E 2-sn-glycero-3-phosphocholine (PEIPC) 1, a compound that plays a role in endothelial activation in atherosclerosis, has been carried out using a PMB ether as the key protecting group. Opening of an intermediate with pentylamine shows that the allylic epoxide is the position of attack by nucleophiles.