1061330-14-0Relevant articles and documents
Improved synthesis of the epoxy isoprostane phospholipid PEIPC and its reactivity with amines
Jung, Michael E.,Berliner, Judith A.,Koroniak, Lukasz,Gugiu, B. Gabriel,Watson, Andrew D.
, p. 4207 - 4209 (2008)
(Chemical Equation Presented) An improved synthesis of the naturally occurring hydroxy ketone 1-palmitoyl-2-(5,6)-epoxyisoprostane E 2-sn-glycero-3-phosphocholine (PEIPC) 1, a compound that plays a role in endothelial activation in atherosclerosis, has been carried out using a PMB ether as the key protecting group. Opening of an intermediate with pentylamine shows that the allylic epoxide is the position of attack by nucleophiles.