106184-48-9Relevant academic research and scientific papers
Practical bromination of arylhydroxylamines with SOBr2 towards ortho-bromo-anilides
Du, Yuanbo,Feng, Lei,Gao, Hongyin,Guo, Lirong,Lu, Haifeng,Xi, Zhenguo
, (2021/05/19)
A facile approach for synthesizing ortho-bromoanilides from readily available aryhydroxylamines and thionyl bromide is demonstrated in this work. Mild reaction conditions and broad scope of substrates ranging from heterocyclic structures to pharmaceutics-potential motifs are used in the reactions of this paper. Efficient bromination of ortho C–H bonds of the aryhydroxylamines has been achieved. Ortho-bromoanilide products were obtained in good to excellent yields, and model scaled-up reactions of this synthetic approach are shown in this work.
Ortho-halogenated arylamine compound and synthesis method thereof
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Paragraph 0111-0115; 0156-0171, (2021/08/06)
The present invention relates to an ortho-halogenated arylamine compound and a synthesis method thereof. The ortho-halogenated arylamine compound has a structure represented by a formula (III), and in the formula (III), X is Cl or Br, Ar is one of substituted naphthyl, phenyl and heteroaryl, and R is one of a benzoyl group, an acetyl group, a pivaloyl group, an ester group, a t-butyloxycarbonyl group, a carbobenzoxy group and a methyl group. According to the invention, cheap and easily available thionyl dihalide reacts with the aryl hydroxylamine compound, efficient synthesis of o-haloarylamine is realized under mild conditions, the universality is good, and various functional groups can well tolerate.
