18271-22-2

Basic information

• Product Name: N-2-naphthylbenzamide
• Synonyms: N-2-naphthylbenzamide;NSC99837;N-(2-Naphtyl)benzamide
• CAS NO: 18271-22-2
• Molecular Formula: C₁₇H₁₃NO
• Molecular Weight: 247.29122
• EINECS: 242-151-7
• Mol File: 18271-22-2.mol
• Article Data: 35

Chemical Properties

• Boiling Point: 347.6°Cat760mmHg
• Flash Point: 210.2°C
• Appearance: /
• Density: 1.221g/cm³
• Vapor Pressure: 5.31E-05mmHg at 25°C
• Refractive Index: 1.705
• CAS DataBase Reference: N-2-naphthylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-2-naphthylbenzamide(18271-22-2)
• EPA Substance Registry System: N-2-naphthylbenzamide(18271-22-2)

Safety Data

• Hazardous Substances Data: 18271-22-2(Hazardous Substances Data)

Usage

General Description

N-2-naphthylbenzamide, also known as 2-Naphthylbenzamide, is a chemical compound with the molecular formula C18H13NO. It is a white to off-white powder that is insoluble in water but soluble in organic solvents. N-2-naphthylbenzamide is primarily used as an intermediate in the pharmaceutical industry, particularly in the synthesis of various drugs. It is also used as a reagent in organic synthesis, and as a UV absorber in plastics and coatings. Additionally, N-2-naphthylbenzamide has been studied for its potential anti-inflammatory and antiviral properties, making it a compound of interest in the field of medicinal chemistry. Overall, N-2-naphthylbenzamide is a versatile chemical with a range of applications in both industry and research.

InChI:InChI=1/C17H13NO/c19-17(14-7-2-1-3-8-14)18-16-11-10-13-6-4-5-9-15(13)12-16/h1-12H,(H,18,19)

Upstream product

• 98-88-4 benzoyl chloride 
• 91-59-8 naphthalen-2-ylamine 
• 614-28-8 N-benzoylbenzamide 
• 3201-48-7 O-methyl benzoylcarbamothioate 
• 18039-42-4 5-Phenyl-1H-tetrazole 
• 580-13-2 2-bromonaphthalene 
• 55-21-0 benzamide 
• 98-95-3 nitrobenzene 
• 7647-01-0 hydrogenchloride 
• 60-29-7 diethyl ether 
• 860723-67-7 N-(naphthalen-2-yl)benzothioamide 
• 100-47-0 benzonitrile 
• 134-32-7 1-amino-naphthalene 
• 93-97-0 benzoic acid anhydride 

Downstream Products

• 130576-37-3 N-chloro-N-[2]naphthyl-benzamide 
• 1934-88-9 N-(2-naphthyl)benzimidoyl chloride 
• 22440-22-8 3-phenyl-2H-benzo[f]quinazolin-1-one 
• 2217-43-8 6-amino-1,2,3,4-tetrahydronaphthalene 
• 860723-67-7 N-(naphthalen-2-yl)benzothioamide 
• 106184-48-9 N-(1-bromonaphthalen-2-yl)benzamide 
• 109394-58-3 N-(5,6,7,8-tetrahydronaphthalen-2-yl)benzamide 
• 6299-41-8 N-(1-nitronaphthalen-2-yl)benzamide 
• 512795-57-2 N-(1-bromo-[2]naphthyl)-thiobenzamide 
• 119656-54-1 N-Benzoyl-N-(2-naphthyl)glycine 
• 88741-38-2 2-phenylnaphtho[2,3-d]oxazole 

Relevant articles and documents

Iron-catalyzed cross-coupling of N?methoxy amides and arylboronic acids for the synthesis of N-aryl amides

An efficient iron-catalyzed synthesis of N-aryl amides from N?methoxy amides and arylboronic acids is developed. FeCl3 is used as the sole catalyst for the cross-coupling reaction between N?methoxy amides and arylboronic acids without any other

Metal-free transamidation of benzoylpyrrolidin-2-one and amines under aqueous conditions

N-Acyl lactam amides, such as benzoylpyrrolidin-2-one, benzoylpiperidin-2-one, and benzoylazepan-2-one reacted with amines in the presence of DTBP and TBAI to afford the transamidated products in good yields. The reactions were conducted under aqueous conditions and good functional group tolerance was achieved. Both aliphatic and aromatic primary amines displayed good activity under metal-free conditions. A radical reaction pathway is proposed.

N-Heterocyclic Carbene/Cobalt Cooperative Catalysis for the Chemo- and Regioselective C?N Bond Formation between Aldehyde and Amines/Amides

A novel methodology for the construction of various secondary (4 examples), tertiary amides (31 examples), and imides (16 examples) by a Cobalt(II) catalyzed oxidative amide coupling in aqueous media. The Co(III)-TMC was reacted with N-Heteroatom Carbene to form active catalyst Co(II)NHC-TMC in situ which involves in the coordination with Breslow's intermediate and SET for the activation of aldehyde and amides. The mechanism for activation of amide and amine differs on the basis of SET based nucleophilic addition and ligand exchange respectively. The regeneration of the catalyst was achieved using Fe(III)(EDTA)-H2O2 as oxidant. The use of Co(II)TMC-O2 was also found equally efficient in the process. The method is found regioselective for N?H activation in the presence of equally susceptible ortho-C?H bond activation. And amines were found more susceptible then the corresponding amide for the reaction.