1062307-75-8

Upstream product

• 6768-20-3 diethyl 2-chlorobenzylidene malonate 
• 105-53-3 diethyl malonate 
• 89-98-5 2-chloro-benzaldehyde 
• 1062307-62-3 diethyl 2-(1-(2-chlorophenyl)-2-nitroethyl)malonate 

Downstream Products

• 28311-22-0 4-(2-chlorophenyl)pyrrolidin-2-one 

Relevant academic research and scientific papers

Efficient synthesis of β-aryl-γ-lactams and their resolution with (S)-Naproxen: Preparation of (R)- and (S)-Baclofen

An efficient synthesis of enantiomerically-pure β-aryl-γ-lactams is described. The principal feature of this synthesis is the practical resolution of β-aryl-γ-lactams with (S)-Naproxen. The procedure is based on the Michael addition of nitromethane to benzylidenemalonates, which was easily obtained, followed by the reduction of the γ-nitroester in the presence of Raney nickel and the subsequent saponification/decarboxylation reaction. The utility of this methodology was highlighted by the preparation of enantiomerically-pure (R)- and (S)-Baclofen hydrochloride.

Tandem reductive cyclisation of diethyl 2-(2-nitro-1-arylethyl)malonate by zinc and ammonium chloride in aqueous medium

A tandem reductive cyclisation of diethyl 2-(2-nitro-1-arylethyl)malonate by zinc and ammonium chloride in aqueous medium leading to a one pot synthesis of ethyl 2-oxo-4-arylpyrrolidine-3-carboxylate in good yield has been described.