1062608-42-7 Usage
Description
5-Bromo-3-iodopyrazin-2-amine is a heterocyclic organic compound characterized by a molecular formula of C4H3BrIN4. It features a pyrazine ring with bromine and iodine substituents, which endows it with unique structural and reactivity properties. 5-Bromo-3-iodopyrazin-2-amine is recognized for its role as a building block in the synthesis of various pharmaceuticals and bioactive molecules, making it a valuable intermediate in the development of complex organic compounds.
Uses
Used in Organic Synthesis:
5-Bromo-3-iodopyrazin-2-amine is used as a key intermediate in organic synthesis for the creation of complex organic compounds. Its unique structure and reactivity contribute to the formation of diverse chemical entities with potential applications across various fields.
Used in Medicinal Chemistry Research:
In the realm of medicinal chemistry, 5-Bromo-3-iodopyrazin-2-amine serves as a building block for the development of pharmaceuticals and bioactive molecules. Its ability to modify the properties of these molecules enhances their therapeutic potential, making it an essential component in drug discovery and development processes.
Used in Drug Discovery and Development:
5-Bromo-3-iodopyrazin-2-amine is utilized as a valuable intermediate in drug discovery and development due to its capacity to alter the characteristics of bioactive molecules. This modification can lead to the enhancement of their efficacy, selectivity, and other pharmacological properties, which is crucial for the creation of novel therapeutic agents.
Used in Material Science:
Although not explicitly mentioned in the provided materials, the compound's unique structure and reactivity may also find applications in material science. Its potential uses could include the development of new materials with specific properties, such as those with altered electronic, optical, or mechanical characteristics.
Used in Chemical Engineering:
Similarly, the compound's properties might be harnessed in chemical engineering for various applications. This could involve the creation of new chemical processes or the improvement of existing ones, taking advantage of the compound's reactivity and structural features to achieve more efficient or effective outcomes.
Check Digit Verification of cas no
The CAS Registry Mumber 1062608-42-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,6,2,6,0 and 8 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1062608-42:
(9*1)+(8*0)+(7*6)+(6*2)+(5*6)+(4*0)+(3*8)+(2*4)+(1*2)=127
127 % 10 = 7
So 1062608-42-7 is a valid CAS Registry Number.
1062608-42-7Relevant articles and documents
Synthesis method of heterocyclic substituted coelenterazine compound
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Paragraph 0132-0133, (2021/10/27)
The invention provides a compound, which is a compound as shown in a formula (I), or a stereoisomer, a geometric isomer, a tautomer, a nitrogen oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug of the compound as shown in the formula (I). The compound and 2-aminopyrazine can be subjected to one-step cyclization under an acidic condition, and various R-2-position heterocyclic ring or heteroaromatic ring substituted coelenterazine derivatives can be rapidly generated.
Structure-activity-relationship studies around the 2-amino group and pyridine core of antimalarial 3,5-diarylaminopyridines lead to a novel series of pyrazine analogues with oral in vivo activity
Younis, Yassir,Douelle, Frederic,González Cabrera, Diego,Le Manach, Claire,Nchinda, Aloysius T.,Paquet, Tanya,Street, Leslie J.,White, Karen L.,Zabiulla, K. Mohammed,Joseph, Jayan T.,Bashyam, Sridevi,Waterson, David,Witty, Michael J.,Wittlin, Sergio,Charman, Susan A.,Chibale, Kelly
supporting information, p. 8860 - 8871 (2013/12/04)
Replacement of the pyridine core of antimalarial 3,5-diaryl-2- aminopyridines led to the identification of a novel series of pyrazine analogues with potent oral antimalarial activity. However, other changes to the pyridine core and replacement or substitution of the 2-amino group led to loss of antimalarial activity. The 3,5-diaryl-2-aminopyrazine series showed impressive in vitro antiplasmodial activity against the K1 (multidrug resistant) and NF54 (sensitive) strains of Plasmodium falciparum in the nanomolar IC50 range of 6-94 nM while also demonstrating good in vitro metabolic stability in human liver microsomes. In the Plasmodium berghei mouse model, this series generally exhibited good efficacy at low oral doses. One of the frontrunner compounds, 4, displayed potent in vitro antiplasmodial activity with IC 50 values of 8.4 and 10 nM against the K1 and NF54 strains, respectively. When evaluated in P. berghei-infected mice, compound 4 was completely curative at an oral dose of 4 × 10 mg/kg.
