106296-39-3

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 4126-60-7 methyl β-benzyloxypropionate 

Downstream Products

• 106296-43-9 (2S,3R,4R)-4,5-Bis-benzyloxy-2-benzyloxymethyl-3-hydroxy-pentanoic acid methyl ester 
• 106296-42-8 (2R,3R,4R)-4,5-Bis-benzyloxy-2-benzyloxymethyl-3-hydroxy-pentanoic acid methyl ester 
• 100-51-6 benzyl alcohol 

Relevant academic research and scientific papers

MgBr2-Promoted Addition of Heterosubstituted Methylketene Silyl Acetals to Alkoxy Aldehydes. Diastereoselective Synthesis of 3,4-Syn 2-Methylene- and 2-(Alkoxymethyl)-3-hydroxy-4-alkoxy Esters

The MgBr2-mediated addition of 2- or 3-(methylthio)-substituted ketene silyl acetals 3 and 4 to α-alkoxy and α,β-dialkoxy aldehydes, followed by oxidation and elimination of methanesulfenic acid, gave 3,4-syn 2-methylene-3-hydroxy-4-alkoxy esters 9 and 11 with very high stereoselectivity (up to 100:1) and in good chemical yields.The same diastereofacial selection is at work in the analogous additions of ketene methyl silyl acetal 5, which affords 3,4-syn 2--3-hydroxy-4-alkoxy esters 12-15.