106352-17-4

Upstream product

• 5294-56-4 2-(1-phenylethylidene)malonic acid diethyl ester 
• 685-87-0 Diethyl 2-bromomalonate 
• 536-74-3 phenylacetylene 
• 98-86-2 acetophenone 

Downstream Products

• 226920-88-3 diethyl 3-cyano-2-phenylpropene-1,1-dicarboxylate 
• 226920-99-6 ethyl 1-benzoyl-5-cyano-1,2-dihydro-6-mercapto-2-oxo-4-phenyl-pyridine-3-carboxylate 
• 226921-01-3 ethyl 5-cyano-1,2-dihydro-2-oxo-4-phenyl-6-trichloromethylpyridine-3-carboxylate 
• 298184-04-0 2-{2-[(4-chloro-phenyl)-hydrazono]-1-phenyl-2-thiocyanato-ethylidene}-malonic acid diethyl ester 
• 298184-07-3 ethyl 1-benzoyl-1,2-dihydro-2-oxo-4-phenyl-6-thiol-5-thiocyanatopyridine-3-carboxylate 
• 298184-03-9 2-[1-phenyl-2-(phenyl-hydrazono)-2-thiocyanato-ethylidene]-malonic acid diethyl ester 
• 298184-10-8 ethyl 1H-2-oxo-4-phenyl-5-thiocyanato-6-trichloromethylpyridine-3-carboxylate 

Relevant academic research and scientific papers

Zinc-mediated addition of diethyl bromomalonate to alkynes for the cascade reaction towards polysubstituted pyranones and tetracarbonyl derivatives

The zinc-mediated regioselective addition reactions of diethyl bromomalonate and aromatic and aliphatic alkynes were investigated for the synthesis of vinyl malonates. When the vinyl organo-zinc intermediates were reacted with acid chlorides 2H-pyran-2-ones were obtained while the application of oxalyl chloride and an amine led to tetracarbonyl derivatives in a one-pot multi-step reaction sequence. The Royal Society of Chemistry 2014.

New routes to polyfunctionally substituted benzene, pyridazines and thiophene derivatives

Diethyl 2-phenyl-3-thiocyanopropene-1,1-dicarboxylate (3) as a key precursor in heterocyclic synthesis. The applicability and synthetic potency of 3 are studied to afford unique heterocyclic compounds.

Diethyl 2-aryl-3-cyanopropene-1,1-dicarboxylates: New versatile precursors in heterocyclic synthesis

An expeditious synthetic route for the title precursor is reported. It provides access to a variety of polyfunctionally substituted pyridines, pyridazines, pyrazolopyridines, thiophenes, and thienopyridines.