5294-56-4Relevant academic research and scientific papers
Asymmetric Hydrogenation of ?-Aryl Alkylidene Malonate Esters: Installing an Ester Group Significantly Increases the Efficiency
Zhao, Qian-Kun,Wu, Xiong,Li, Lin-Ping,Yang, Fan,Xie, Jian-Hua,Zhou, Qi-Lin
supporting information, p. 1675 - 1680 (2021/03/08)
Herein, we report a practical method for efficient asymmetric hydrogenation of β-aryl alkylidene malonates. With a site-specifically tailored chiral spiro iridium catalyst, a series of β-aryl alkylidene malonate esters were hydrogenated to afford chiral m
Indium (III) mediated Markovnikov addition of malonates and β-ketoesters to terminal alkynes and the formation of Knoevenagel condensation products
Zhang, Ji,Blazecka, Peter G.,Angell, Paul,Lovdahl, Mark,Curran, Timothy T.
, p. 7807 - 7813 (2007/10/03)
The indium(III) triflate mediated addition of active methylene compounds to terminal alkynes has been expanded to use malonates and low boiling terminal alkynes to form the Markovnikov addition products. Indium(III) chloride and indium(III) bromide were also found to be efficient catalysts. Knoevenagel condensation products were isolated when reactions involved a simple malonate or β-ketoester.
Diethyl 2-aryl-3-cyanopropene-1,1-dicarboxylates: New versatile precursors in heterocyclic synthesis
Erian, Ayman W.,Araki, Vivian F.,Aziz, Suzan I.,Sherif, Sherif M.
, p. 661 - 669 (2007/10/03)
An expeditious synthetic route for the title precursor is reported. It provides access to a variety of polyfunctionally substituted pyridines, pyridazines, pyrazolopyridines, thiophenes, and thienopyridines.
New routes to polyfunctionally substituted benzene, pyridazines and thiophene derivatives
Erian, Ayman Wahba,Abdel, Abu Zeid,Hassanien, Baset,Mohamed, Nadia Ragab
, p. 147 - 155 (2007/10/03)
Diethyl 2-phenyl-3-thiocyanopropene-1,1-dicarboxylate (3) as a key precursor in heterocyclic synthesis. The applicability and synthetic potency of 3 are studied to afford unique heterocyclic compounds.
Specific Features of Reactions of Butyl- and Phenylacetylenes with CH-Acids
Badanyan,Chobanyan,Tirakyan,Danielyan
, p. 17 - 20 (2007/10/03)
The reactions of butyl- and phenylacetylenes with cyanoacetic, malonic, and acetoacetic esters and acetylacetone in a polar solvent in the presence of mercuric acetate were studied. Intramolecular cyclization of unsaturated dicarbonyl compounds formed at
Evidence of transannular bonding interaction between two sulfur atoms on photolysis of naphtho[1,8-ef][1,4]dithiepins
Fujii, Takayoshi,Takahashi, Ohgi,Furukawa, Naomichi
, p. 6233 - 6239 (2007/10/03)
Naphtho[1,8-ef][1,4]dithiepins 5 were prepared by the reaction of naphtho[1,8-de]-1,3-dithiins 3 with diethyl diazomalonate in the presence of copper acetylacetonate. The X-ray crystallographic analysis of 2,3-dihydro-2,2-bis(ethoxycarbonyl)-3-phenylnaphtho[1,8-ef][1,4]dithie pin (5a) revealed that the S···S distance is shorter than the sum of their van der Waals radii, indicating that compounds 5 have a strong through-space interaction between the two sulfur atoms. Direct irradiation of 5 with a 500 W high-pressure mercury lamp (313 nm) at room temperature gave the corresponding olefins 6 and naphtho[1,8-cd]-1,2-dithiole (1) quantitatively. The quantum yields of the consumption of 5a and the formation of 6a and 1 were 0.34. The mechanism of this reaction was investigated by examining the effect of sensitization and light intensity. The results indicate that the reaction may proceed by a one-photon process from an excited singlet state. Ab initio calculations were carried out on model compound 7, and it was shown that the excitation to the S1 state causes a bonding interaction between the two sulfur atoms, making the reaction possible.
