106352-39-0

Basic information

• Product Name: 4,4,4-trifluoro-3-methyl-1-phenylbutan-1-one
• Synonyms: 4,4,4-trifluoro-3-methyl-1-phenylbutan-1-one
• CAS NO: 106352-39-0
• Molecular Weight: 216.203
• Mol File: 106352-39-0.mol

Chemical Properties

• CAS DataBase Reference: 4,4,4-trifluoro-3-methyl-1-phenylbutan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4,4-trifluoro-3-methyl-1-phenylbutan-1-one(106352-39-0)
• EPA Substance Registry System: 4,4,4-trifluoro-3-methyl-1-phenylbutan-1-one(106352-39-0)

Safety Data

• Hazardous Substances Data: 106352-39-0(Hazardous Substances Data)

Upstream product

• 1771-65-9 2-methyl-4-oxo-4-phenylbutanoic acid 
• 1680206-12-5 Grushin’s reagent 
• 495-41-0 1-phenylbut-2-en-1-one 
• 147531-11-1 trifluoromethanesulfonic acid diphenyl(trifluoromethyl)sulfonium salt 
• 197566-47-5 (E)-4,4,4-trifluoro-3-methyl-1-phenyl-2-buten-1-ol 
• 6048-29-9 triphenylphenacylphosphonium bromide 
• 851645-72-2 (E)-4,4,4-trifluoro-3-methyl-1-phenyl-2-buten-1-one 

Downstream Products

• 106352-41-4 (2R,3S)-4,4,4-Trifluoro-2-hydroxy-3-methyl-1-phenyl-butan-1-one 
• 106352-41-4 (2S,3S)-4,4,4-Trifluoro-2-hydroxy-3-methyl-1-phenyl-butan-1-one 

Relevant articles and documents

Silver-Catalyzed Decarboxylative Trifluoromethylation of Aliphatic Carboxylic Acids

The silver-catalyzed decarboxylative trifluoromethylation of aliphatic carboxylic acids is described. With AgNO3 as the catalyst and K2S2O8 as the oxidant, the reactions of aliphatic carboxylic acids with (bpy)C

Base-Catalyzed Stereospecific Isomerization of Electron-Deficient Allylic Alcohols and Ethers through Ion-Pairing

A mild base-catalyzed strategy for the isomerization of allylic alcohols and allylic ethers has been developed. Experimental and computational investigations indicate that transition metal catalysts are not required when basic additives are present. As in the case of using transition metals under basic conditions, the isomerization catalyzed solely by base also follows a stereospecific pathway. The reaction is initiated by a rate-limiting deprotonation. Formation of an intimate ion pair between an allylic anion and the conjugate acid of the base results in efficient transfer of chirality. Through this mechanism, stereochemical information contained in the allylic alcohols is transferred to the ketone products. The stereospecific isomerization is also applicable for the first time to allylic ethers, yielding synthetically valuable enantioenriched (up to 97% ee) enol ethers.

Regioselective 1,4-trifluoromethylation of α,β-unsaturated ketones via a S-(trifluoromethyl)diphenylsulfonium salts/copper system

Regioselective conjugate 1,4-trifluoromethylation of α,β- unsaturated ketones by the use of shelf-stable electrophilic trifluoromethylating reagents, S-(trifluoromethyl)diphenylsulfonium salts and copper under mild conditions is described. A wide range of acyclic aryl-aryl-enones and aryl-alkyl-enones were converted into β- trifluoromethylated ketones in low to moderate yields.

Synthesis of β-CF3 ketones from trifluoromethylated allylic alcohols by ruthenium catalyzed isomerization

This work describes the optimization process for the synthesis of β-trifluoromethylated ketones from trifluoromethylated allylic alcohols. This transformation proceeds through a ruthenium catalyzed isomerization under mild conditions with high atom econom

Ruthenium-catalyzed redox isomerization of trifluoromethylated allylic alcohols: Mechanistic evidence for an enantiospecific pathway

Transfer news: A synthetic approach to chiral β-CF3- substituted saturated carbonyl compounds has been developed in which ruthenium complexes efficiently catalyze the redox isomerization of CF3-bearing allylic alcohols by an intramol