106419-75-4

Upstream product

• 105-53-3 diethyl malonate 
• 52289-93-7 o-Methoxybenzyl bromide 
• 609-08-5 Diethyl methylmalonate 
• 612-16-8 (2-methoxyphenyl)methanol 
• 95-48-7 ortho-cresol 
• 578-58-5 2-methylmethoxybenzene 

Downstream Products

• 106419-78-7 C₁₂H₁₈O₃ 
• 1239982-47-8 o-CH₃OC₆H₄CH₂C(CH₃)(CH₂OTs)2 
• 1254940-94-7 3-(bromomethyl)-3-methylchroman 
• 1254940-95-8 1-(3-bromo-2-(bromomethyl)-2-methylpropyl)-2-methoxybenzene 
• 108239-42-5 5-(2-methoxy-benzyl)-5-methyl-barbituric acid 

Relevant academic research and scientific papers

Nickel-Catalyzed Benzylic Substitution of Benzyl Esters with Malonates as a Soft Carbon Nucleophile

The nickel-catalyzed benzylic substitution of benzyl alcohol derivatives with a soft carbon nucleophile is extremely rare compared to that with a hard carbon nucleophile. We have achieved the nickel-catalyzed benzylic substitution of benzyl esters with malonates as a soft carbon nucleophile. Primary and secondary benzyl 2,3,4,5,6-pentafluorobenzoates as well as a wide variety of malonate derivatives were well tolerated in the nickel-catalyzed reaction, providing the corresponding alkylation products in 46-86% yields (34 examples). Additionally, we propose a possible reaction mechanism that would undergo via the ??1- A nd ??3-benzylnickel intermediates.

Synthesis and characterization of chroman-containing compounds and their preliminary assessment of cytotoxicity toward two human cancer cell lines

A series of chroman derivatives were synthesized by employing o-methyl phenol as a precursor. These compounds were fully characterized using IR, NMR spectroscopic techniques, and elemental analysis. Mechanisms for the formation of the chroman moiety of these compounds were also proposed. MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay was used to estimate their cytotoxicity toward two cancer cell lines: human ovarian cancer (A2780) and human cervical cancer (Hela).

A rare bond between a soft metal (FeI) and a relatively hard base (RO-, R = phenolic moiety)

Reacting a bidentate ligand H2L, 2-(2-methoxybenzyl)-2- methylpropane-1,3-dithiol, with Fe3(CO)12 formed a diiron hexacarbonyl complex (1Me) from which a diiron hexacarbonyl complex (1H) pendant with a phenolic group was derived via in-situ demethylation. Further deprotonation of complex 1H gave a diiron pentacarbonyl species (1) in which a rare bond between the soft metal FeI and the relatively hard base phenolate formed, FeI-OR (R = phenolic moiety). This bonding may be a suitable mimic of the bonding feature, {FeIFeI}R-OH/ OH2 found in the [FeFe]-hydrogenase.