106486-93-5

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 13754-86-4 1,5,6,7-tetrahydro-indol-4-one 
• 106154-13-6 1-[(4-methylbenzene)sulfonyl]-4-[(trimethylsilyl)oxy]-4,5,6,7-tetrahydro-1H-indole-4-carbonitrile 
• 35577-89-0 1-[(4-methylbenzene)sulfonyl]-4,5,6,7-tetrahydro-1H-indol-4-one 

Downstream Products

• 31271-86-0 1-[(4-methylphenyl)sulfonyl]-1H-indole-4-carbonitrile 
• 1349368-76-8 ethyl 1-[(4-methylbenzene)sulfonyl]-4,5,6,7-tetrahydro-1H-indole-4-carboxylate 

Relevant academic research and scientific papers

PYRANOPYRAZOLE AND PYRAZOLOPYRIDINE IMMUNOMODULATORS FOR TREATMENT OF AUTOIMMUNE DISEASES

Pyranoyrazoles and pyrazolopyridines of formula I or formula II are disclosed: (I), (II) These compounds inhibit Coagulation Factor Xlla in the presence of thrombin and other coagulation factors. They are useful to treat autoimmune diseases.

AMINOACYLINDAZOLE IMMUNOMODULATORS FOR TREATMENT OF AUTOIMMUNE DISEASES

2-Acylindazole compounds of formula I or formula II are disclosed. These compounds inhibit Coagulation Factor XIIa. They are useful to treat autoimmune diseases.

SYNTHESIS OF 4-CYANOINDOLE FROM 4-OXO-4,5,6,7-TETRAHYDROINDOLE DERIVATIVES

4-Oxo-4,5,6,7-tetrahydroindoles are first converted to cyanohydrin silyl ethers and subsequent elimination and/or oxidation produced 4-cyanoindole.