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1453175-46-6

C24H29N3O3S is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1453175-46-6 Structure

  • Basic information

    1. Product Name: C24H29N3O3S
    2. Synonyms: C24H29N3O3S
    3. CAS NO:1453175-46-6
    4. Molecular Formula:
    5. Molecular Weight: 439.579
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1453175-46-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: C24H29N3O3S(CAS DataBase Reference)
    10. NIST Chemistry Reference: C24H29N3O3S(1453175-46-6)
    11. EPA Substance Registry System: C24H29N3O3S(1453175-46-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1453175-46-6(Hazardous Substances Data)

1453175-46-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1453175-46-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,5,3,1,7 and 5 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1453175-46:
(9*1)+(8*4)+(7*5)+(6*3)+(5*1)+(4*7)+(3*5)+(2*4)+(1*6)=156
156 % 10 = 6
So 1453175-46-6 is a valid CAS Registry Number.

1453175-46-6Downstream Products

1453175-46-6Relevant articles and documents

Identification of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with no evidence of CYP3A4 time-dependent inhibition and improved aqueous solubility

Zak, Mark,Liederer, Bianca M.,Sampath, Deepak,Yuen, Po-Wai,Bair, Kenneth W.,Baumeister, Timm,Buckmelter, Alexandre J.,Clodfelter, Karl H.,Cheng, Eric,Crocker, Lisa,Fu, Bang,Han, Bingsong,Li, Guangkun,Ho, Yen-Ching,Lin, Jian,Liu, Xiongcai,Ly, Justin,O'Brien, Thomas,Reynolds, Dominic J.,Skelton, Nicholas,Smith, Chase C.,Tay, Suzanne,Wang, Weiru,Wang, Zhongguo,Xiao, Yang,Zhang, Lei,Zhao, Guiling,Zheng, Xiaozhang,Dragovich, Peter S.

, p. 529 - 541 (2015/03/05)

Herein we report the optimization efforts to ameliorate the potent CYP3A4 time-dependent inhibition (TDI) and low aqueous solubility exhibited by a previously identified lead compound from our NAMPT inhibitor program (1, GNE-617). Metabolite identification studies pinpointed the imidazopyridine moiety present in 1 as the likely source of the TDI signal, and replacement with other bicyclic systems was found to reduce or eliminate the TDI finding. A strategy of reducing the number of aromatic rings and/or lowering c Log D7.4 was then employed to significantly improve aqueous solubility. These efforts culminated in the discovery of 42, a compound with no evidence of TDI, improved aqueous solubility, and robust efficacy in tumor xenograft studies.

AMIDO-BENZYL SULFONE AND SULFOXIDE DERIVATIVES

-

, (2013/09/12)

The present invention relates to certain amido-benzyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

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