106578-75-0

Upstream product

• 75840-25-4 (Z)-3-amino-4,4,4-trifluoro-1-phenylbut-2-en-1-one 
• 74-89-5 methylamine 
• 144864-93-7 1-phenyl-4,4,4-trifluorobutane-1,3-dione 
• 62-53-3 aniline 
• 6919-61-5 N-methoxy-N-methylbenzamide 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 404-24-0 2,2,2-trifluoro-N-phenylacetamide 
• 106578-69-2 1-phenyl-1-(N-phenylamino)-4,4,4-trifluoro-1-buten-3-one 
• 75840-25-4 (Z)-3-amino-4,4,4-trifluoro-1-phenylbut-2-en-1-one 

Relevant academic research and scientific papers

New approaches to β-trifluoromethylated enone derivatives

β-Trifluoromethylated enaminones 1 were prepared stereospecifically or high stercoselectively in 31-92% yields from the reaction of Weinreb amides with trifluoropropynyl lithium, followed by quenching with H2O in the presence of amine derivativ

Interaction of fluoroalkyl-containing β-diketones with amines

The composition of products of the interaction of asymmetric fluoroalkyl-containing β-diketones with amines was studied. Mixtures of regioisomeric β-aminovinylketones and products of cleavage and secondary condensation are formed, depending on the temperature, the solvent, the nature of the fluorinated and nonfluorinated substituents in the β-diketone, and the basicity of the amine. The major product is a β-aminovinylketone in which the NH2 group is removed from the fluoroalkyl substituent. No β-aminovinylimines, products of condensation involving two electrophilic centers, were observed.