106595-73-7Relevant academic research and scientific papers
Combining structure- and property-based optimization to identify selective FLT3-ITD inhibitors with good antitumor efficacy in AML cell inoculated mouse xenograft model
Heng, Hao,Wang, Zhijie,Li, Hongmei,Huang, Yatian,Lan, Qingyuan,Guo, Xiaoxing,Zhang, Liang,Zhi, Yanle,Cai, Jiongheng,Qin, Tianren,Xiang, Li,Wang, Shuxian,Chen, Yadong,Lu, Tao,Lu, Shuai
, p. 248 - 267 (2019/05/21)
FLT3 mutation is among the most common genetic mutations in acute myeloid leukemia (AML), which is also related with poor overall survival and refractory in AML patients. Recently, FLT3 inhibitors have been approved for AML therapy. Herein, a series of new compounds with pyrazole amine scaffold was discovered, which showed potent inhibitory activity against FLT3-ITD and significant selectivity against both FLT3-ITD and AML cells expressing FLT3-ITD. Compound 46, possessing the most promising cellular activity, blocked the autophosphorylation of FLT3 pathway in MV4-11 cell line. Furthermore, the apoptosis and downregulation of P-STAT5 were also observed in tumor cells extracted from the MV4-11 cell xenografts model upon compound 46 treatment. Compound 46 was also metabolically stable in vitro and suppressed tumor growth significantly in MV4-11 xenografts model in vivo. Compound 46 showed no toxicity to the viscera of mice and caused no decrease in body weight of mice. In conclusion, the results of this study could provide valuable insights into discovery of new FLT3 inhibitors, and compound 46 was worthy of further development as potential drug candidate to treat AML.
PIGMENT DISPERSANT, AND PIGMENT COMPOSITION, COLORING COMPOSITION AND COLOR FILTER USING THE SAME
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Paragraph 0180; 0181, (2016/11/09)
PROBLEM TO BE SOLVED: To provide a pigment dispersant that exhibits an extremely good characteristic in enhancing the dispersibility of pigment, to provide a pigment composition, produced by using the pigment dispersant, that is excellent in the contrast
The pigment composition, a colored composition, color filter
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Paragraph 0143; 0144, (2016/11/14)
PROBLEM TO BE SOLVED: To provide a pigment composition that is excellent, when used for a color filter, in its contrast ratio and luminance, has a good heat resistance and light stability, and does not generate a coated film foreign body, as well as to pr
