106691-15-0

Upstream product

• 1124-15-8 3,5-dimethyl-1H-pyrazole-1-carbothioamide 
• 99-81-0 4-Nitrophenacyl bromide 
• 21566-36-9 2,2-dibromo-1-(4-nitro-phenyl)-ethanone 
• 110944-98-4 2-iodo-1-(4-nitrophenyl)ethanone 
• 123-54-6 acetylacetone 
• 26049-70-7 2-Hydrazino-4-(4-nitrophenyl)thiazole 

Relevant academic research and scientific papers

β,β-Dibromoketones: A superior alternative to β-bromoketones in hantzsch thiazole synthesis

β,β-Dibromoketones (2) have been found to be a superior alternative to the conventionally used β-bromoketones (1) for performing the Hantzsch thiazole synthesis.1 These crystalline, nonlachrymatory compounds are more reactive than 1 as demonstrated by the

Sodium carbonate-mediated facile synthesis of 4-substituted-2-(3,5- dimethylpyrazol-1-yl)thiazoles under solvent-free conditions

An efficient and facile synthesis of 4-substituted-2-(3,5-dimethylpyrazol- 1-yl)thiazoles 3 was achieved by grinding an equimolar mixture of -haloketones 2 with 3,5-dimethylpyrazol-1-thiocarboxamide 1 in the presence of sodium carbonate under the solvent-

Synthesis and antibacterial activity of some 4-(coumarin-3-yl)/Aryl 2 (3,5-dimethylpyrazol-1-yl)thiazoles

Reaction of 3-(2-bromoacetyl) coumarins (4) with 3,5-dimethylpyrazol-1- thiocarboxamide (5) results in the formation of title compounds 6. 4-Aryl-2-(3,5-dimethylpyrazol-1-yl) thiazoles (8) which could not be synthesized earlier through this method, were obtained by performing the reaction in presence of a base. All the synthesized compounds have shown moderate to significant antibacterial activity against Gram-positive bacteria namely S. aureus and B. subtilis.

Unexpected Formation of α-Thiocyanatoketones in Hantzsch Thiazole Synthesis

The reaction of 3,5-dimethylpyrazole-1-thiocarboxamide (3) with α-haloketones (4) yields the corresponding α-thiocyanatoketones (5) or pyrazoles (1) depending upon nature of the halogen.Many such pyrazole derivatives have erroneously been described as thiazolotriazepines in literature.

Reported Formation of 3-Arylthiazolotriazepines in the Reaction of 2-Hydrazino-4-arylthiazoles with Pentane-2,4-dione: A Reinvestigation

The condensation of 2-hydrazino-4-arylthiazoles (1a-d) with pentane-2,4-dione (6) results in the formation of 2-(3',5'-dimethylpyrazol-1'-yl)-4-arylthiazoles (2a-d) and not the 3-arylthiazolotriazepines (3) as reported.The correct structural assignment is based on PMR, 13CNMR and high resolution mass spectrometry of the products (2a-d).These products have been obtained by an alternate route involving phenacyl bromides (4) and 3,5-dimethylpyrazol-1-thiocarboxamide (5).