106691-15-0

Basic information

• Product Name: 2-(3,5-dimethyl-1H-pyrazol-1-yl)-4-{4-nitrophenyl}-1,3-thiazole
• Synonyms: 2-(3,5-dimethyl-1H-pyrazol-1-yl)-4-{4-nitrophenyl}-1,3-thiazole
• CAS NO: 106691-15-0
• Molecular Formula: C₁₄H₁₂N₄O₂S
• Molecular Weight: 300.33568
• Mol File: 106691-15-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(3,5-dimethyl-1H-pyrazol-1-yl)-4-{4-nitrophenyl}-1,3-thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,5-dimethyl-1H-pyrazol-1-yl)-4-{4-nitrophenyl}-1,3-thiazole(106691-15-0)
• EPA Substance Registry System: 2-(3,5-dimethyl-1H-pyrazol-1-yl)-4-{4-nitrophenyl}-1,3-thiazole(106691-15-0)

Safety Data

• Hazardous Substances Data: 106691-15-0(Hazardous Substances Data)

Upstream product

• 26049-70-7 2-Hydrazino-4-(4-nitrophenyl)thiazole 
• 123-54-6 acetylacetone 
• 1124-15-8 3,5-dimethyl-1H-pyrazole-1-carbothioamide 
• 110944-98-4 2-iodo-1-(4-nitrophenyl)ethanone 
• 21566-36-9 2,2-dibromo-1-(4-nitro-phenyl)-ethanone 
• 99-81-0 4-Nitrophenacyl bromide 

Relevant articles and documents

β,β-Dibromoketones: A superior alternative to β-bromoketones in hantzsch thiazole synthesis

β,β-Dibromoketones (2) have been found to be a superior alternative to the conventionally used β-bromoketones (1) for performing the Hantzsch thiazole synthesis.1 These crystalline, nonlachrymatory compounds are more reactive than 1 as demonstrated by the

Synthesis and antibacterial activity of some 4-(coumarin-3-yl)/Aryl 2 (3,5-dimethylpyrazol-1-yl)thiazoles

Reaction of 3-(2-bromoacetyl) coumarins (4) with 3,5-dimethylpyrazol-1- thiocarboxamide (5) results in the formation of title compounds 6. 4-Aryl-2-(3,5-dimethylpyrazol-1-yl) thiazoles (8) which could not be synthesized earlier through this method, were obtained by performing the reaction in presence of a base. All the synthesized compounds have shown moderate to significant antibacterial activity against Gram-positive bacteria namely S. aureus and B. subtilis.

Reported Formation of 3-Arylthiazolotriazepines in the Reaction of 2-Hydrazino-4-arylthiazoles with Pentane-2,4-dione: A Reinvestigation

The condensation of 2-hydrazino-4-arylthiazoles (1a-d) with pentane-2,4-dione (6) results in the formation of 2-(3',5'-dimethylpyrazol-1'-yl)-4-arylthiazoles (2a-d) and not the 3-arylthiazolotriazepines (3) as reported.The correct structural assignment is based on PMR, 13CNMR and high resolution mass spectrometry of the products (2a-d).These products have been obtained by an alternate route involving phenacyl bromides (4) and 3,5-dimethylpyrazol-1-thiocarboxamide (5).