1124-15-8Relevant articles and documents
Synthesis, characterisation and crystal structure of 3,5-dimethylpyrazole-1-carbothioic acid amide
Chawla, Sukhvinder K.,Kaur, Simrat,Gupta, Nidhi,Hundal, Geeta
, p. 335 - 336 (2007)
3,5-Dimethylpyrazole-1-carbothioic acid amide was obtained (along with acetyl thiosemicarbazide) by the condensation of acetylacetone with thiosemicarbazide and characterised through X-ray diffraction and spectral studies.
Palladium(ii) complexes bearing 1-iminothiolate-3,5-dimethylpyrazoles: Synthesis, cytotoxicity, DNA binding and enzymatic inhibition studies
De Moura, Thales Reggiani,Zanetti, Renan Diego,Silva, Debora Eduarda Soares,De Farias, Renan Lira,Mauro, Antonio Eduardo,Pereira, José Clayston Melo,De Souza, Aline Aparecida,Da Silva Siqueira, Fábio,De Souza Júdice, Wagner Alves,Lima, Mauro Almeida,Rocha, Fillipe Vieira,Deflon, Victor Marcelo,De Godoy Netto, Adelino Vieira
, p. 19891 - 19901 (2020)
Four palladium(ii) compounds of general formulae [PdCl(Ln)(PPh3)] {L1 = 3,5-dimethylpyrazole-1-iminothiolate (1); L2 = 3,5-dimethyl-pyrazole-N-methyl-1-iminothiolate (2); L3 = 3,5-dimethylpyrazole-N-ethyl-1-iminothiolate (3); L4 = 3,5-dimethylpyrazole-N-phenyl-1-iminothiolate (4); and PPh3 = triphenylphosphine} have been synthesized. The novel synthesized compounds have been characterized by C, H and N elemental analysis, 1D (1H and 13C) and 2D (HSQC and HMBC) NMR, MS, FT-IR, and molar electrical conductivity measurements. The molecular structure of complex 3 has been solved by single-crystal X-ray crystallography. The stability of the complexes in solution was studied in a DMSO/D2O (7?:?3) solution after 48 h. The antiproliferative activity of all free ligands and the stable palladium complexes 2-4 was assayed using the human breast tumour cell line MCF-7, lung tumour cell line A549 and human fetal lung fibroblast cell line MRC-5. Complex 3 was more active than cisplatin against MCF-7 cells, whilst palladium compounds 2-4 exhibited no drug response towards A549 cells at concentrations 50 μM. The binding properties of compounds 2 and 3 to ct-DNA have been studied using circular dichroism and fluorescence spectroscopy. The topoisomerase IIα inhibition has been studied for complex 2 and 3. The ability of all complexes to inhibit the activity of cathepsin B and L has also been investigated in this work. Compound 4 inhibited more than 50% of the cathepsin B activity at a concentration of 10 μM. Docking simulations have been carried out to gain more information about the interaction of the complexes and cathepsin B.
Synthesis and antibacterial activity of some 4-(coumarin-3-yl)/Aryl 2 (3,5-dimethylpyrazol-1-yl)thiazoles
Aggarwal, Ranjana,Kumar, Sunil,Sharma, Chetan,Aneja, Kamal R.,Singh, Shiv P.
, p. 331 - 336 (2013/09/24)
Reaction of 3-(2-bromoacetyl) coumarins (4) with 3,5-dimethylpyrazol-1- thiocarboxamide (5) results in the formation of title compounds 6. 4-Aryl-2-(3,5-dimethylpyrazol-1-yl) thiazoles (8) which could not be synthesized earlier through this method, were obtained by performing the reaction in presence of a base. All the synthesized compounds have shown moderate to significant antibacterial activity against Gram-positive bacteria namely S. aureus and B. subtilis.
