106712-03-2Relevant academic research and scientific papers
Stereochemistry and reactivity of the HPA-imine Mannich intermediate
Polyak, Daniel,Phung, Ngan,Liu, Jian,Barrows, Robert,Emge, Thomas J.,Knapp, Spencer
, p. 3879 - 3883 (2017)
Homophthalic anhydride (HPA) typically reacts rapidly with benzalimines to afford the formal [4+2] adduct, a 1,2,3,4-tetrahydroisoquinolin-1-one-4-carboxylic acid. The stereochemical outcome of this reaction is consistent with an open transition state com
A Study and Mechanistic Interpretation of the Electronic and Steric Effects That Determine the Stereochemical Outcome of the Reaction of Schiff Bases with Homophthalic Anhydride and 3-Phenylsuccinic Anhydride
Cushman, Mark,Madaj, Edmund J.
, p. 907 - 915 (2007/10/02)
A study has been undertaken of the electronic and steric effects that determine the ratios of cis- and trans-isoquinolones 9 formed in the condensation of para-substituted Schiff bases 8 with homophthalic anhydride (5).A linear correlation between the rat
